Quantitative Analysis of Climbing Defects in a Drosophila Model of Neurodegenerative Disorders

Surya T. Madabattula; Joel C. Strautman; Andrew M. Bysice; Julia A. O&#8217;Sullivan; Alaura Androschuk; Cory Rosenfelt; Kacy Doucet; Guy Rouleau; Francois Bolduc

doi:10.3791/52741

Rivista

/

Neuroscienze

/

Analisi quantitativa dei difetti arrampicata in un modello Drosophila di malattie neurodegenerative

Quantitative Analysis of Climbing Defects in a Drosophila Model of Neurodegenerative Disorders

JoVE Journal
Neuroscienze

È necessario avere un abbonamento a JoVE per visualizzare questo. Accedi o inizia la tua prova gratuita.

JoVE Journal Neuroscienze

Quantitative Analysis of Climbing Defects in a Drosophila Model of Neurodegenerative Disorders

Analisi quantitativa dei difetti arrampicata in un modello Drosophila di malattie neurodegenerative

Please note that all translations are automatically generated. Click here for the English version.

18,532 Views

•

06:30 min

•

June 13, 2015

DOI:

10.3791/52741-v

DOI:

10.3791/52741-v

•

06:30 min

June 13, 2015

•

17 Views

Surya T. Madabattula¹, Joel C. Strautman¹, Andrew M. Bysice¹, Julia A. O’Sullivan¹, Alaura Androschuk¹, Cory Rosenfelt¹, Kacy Doucet¹, Guy Rouleau², Francois Bolduc¹

¹Department of Pediatrics,University of Alberta, ²Montreal Neurological Institute and Hospital,McGill University

Summary

We present an optimized inexpensive and reliable negative geotaxis assay in Drosophila melanogaster as a model for neurodegenerative disorders. Being more sensitive to mild locomotor defects, this assay will help screen for potential genetic interactions and drug targets.