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Immunology and Infection

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Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic Poly(I:C)

Article DOI: 10.3791/53643-v • 07:13 min • March 25th, 2016
March 25th, 2016 •
*1, *1,2, 1
1Division of Biology and Biological Engineering, California Institute of Technology, 2Harvard Medical School
* These authors contributed equally

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Maternal immune activation (MIA) is a model for an environmental risk factor of autism and schizophrenia. The goal of this article is to provide a step-by-step procedure of how to induce MIA in the pregnant mice in order to enhance the reproducibility of this model.

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Maternal Immune Activation MIA Mice Viral Mimic Poly(I:C) Mid-gestation Stage Neuro-immunology Brain Development Behavior Environmental Risk Factor Autism Schizophrenia Induction Method Timed Mating Pair Estrous Cycle Synchronization Ear Punch Labeling Dark Cycle Body Weight Recording Male Mouse Addition Plug Detection
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