Screening delle nanoparticelle bioattive in cellule immunitarie fagocitiche per gli inibitori della segnalazione di ricetrasmettitori simili
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July 26, 2017
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La segnalazione di TLR (Toll-like receptor) ha un ruolo importante nella fisiopatologia di molte malattie infiammatorie umane e la regolazione delle risposte TLR mediante nanoparticelle bioattive è prevista per essere vantaggiosa in molte condizioni infiammatorie. Le cellule reporter THP-1 forniscono una piattaforma di screening versatile e robusta per identificare nuovi inibitori della segnalazione TLR.
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Cite this Article
Yang, H., Fung, S. Y., Bao, A., Li, Q., Turvey, S. E. Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling. J. Vis. Exp. (125), e56075, doi:10.3791/56075 (2017).
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