Combined Transcranial Magnetic Stimulation and Electroencephalography of the Dorsolateral Prefrontal Cortex

Pantelis Lioumis; Reza Zomorrodi; Itay Hadas; Zafiris J. Daskalakis; Daniel M. Blumberger

doi:10.3791/57983

Stimolazione magnetica transcranica combinata e l'elettroencefalografia della corteccia prefronta...

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JoVE Journal Neuroscience

Combined Transcranial Magnetic Stimulation and Electroencephalography of the Dorsolateral Prefrontal Cortex

Stimolazione magnetica transcranica combinata e l'elettroencefalografia della corteccia prefrontale dorsolaterale

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07:42 min

August 17, 2018

DOI: 10.3791/57983-v

Pantelis Lioumis¹, Reza Zomorrodi¹, Itay Hadas¹, Zafiris J. Daskalakis^1,2, Daniel M. Blumberger^1,2

¹Temerty Centre for Therapeutic Brain Intervention at the Centre for Addiction and Mental Health, ²Department of Psychiatry and Institute of Medical Science, Faculty of Medicine,University of Toronto

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Overview

This protocol describes a method for conducting TMS-EEG studies that assess intracortical excitability through a test-retest design. It aims to provide reliable measures for evaluating neurophysiological functions related to treatments for neuropsychiatric disorders, such as major depression.

Key Study Components

Area of Science

Neuroscience
Clinical neurophysiology
Psychiatry

Background

This study focuses on measuring cortical excitability.
It seeks to understand predictors of response to therapeutic interventions.
The protocol is designed to ensure reproducibility of measurements.
It incorporates TMS and EEG for a comprehensive evaluation of brain functions.

Purpose of Study

To develop reliable methods for assessing changes in cortical excitability.
To aid in identifying neurophysiological signals related to therapeutic responses.
To enhance the understanding of neurophysiological mechanisms in neuropsychiatric treatment.

Methods Used

TMS-EEG as the primary method for measuring cortical excitability.
The biological model involves participants with neuropsychiatric conditions.
Proper electrode preparation, TMS coil calibration, and adjustment of stimulation intensity are critical components.
Key steps include electrode placement, impedance checking, and controlling TMS parameters.
Data is recorded during single-pulse and paired-pulse TMS procedures.

Main Results

The method facilitates reliable monitoring of cortical excitability.
Electrode preparation directly affects signal quality and measurement accuracy.
Significant artifacts may occur during stimulation, necessitating careful coil placement adjustments.
The study optimizes methods for capturing key neurophysiological responses.

Conclusions

The study demonstrates a robust protocol for advancing TMS-EEG research in neuropsychiatry.
It enables deeper insights into cortical excitability and its implications for treatment responses.
The findings are relevant for understanding neuronal mechanisms and improving therapeutic approaches.

Frequently Asked Questions

What are the advantages of using TMS-EEG?

TMS-EEG combines the advantages of both TMS and EEG, allowing for real-time monitoring of cortical excitability and brain activity during stimulation.

How is the biological model implemented in the study?

Participants are selected based on neuropsychiatric conditions, and the TMS procedure is applied to measure changes in their cortical excitability.

What types of data are obtained from this protocol?

The protocol yields data on cortical excitability changes and neurophysiological responses during therapeutic interventions.

How can this method be adapted for different studies?

The method can be adapted by altering stimulation parameters or using different biological models depending on the research focus.

What are the key limitations of this protocol?

Limitations include the potential for artifacts during stimulation and the need for precise electrode placement to ensure accurate data collection.

Il protocollo presentato qui è per gli studi di TMS-EEG che utilizzano paradigmi di progettazione di eccitabilità intracorticale test-retest. L'intento del protocollo è quello di produrre misure di eccitabilità corticale affidabile e riproducibile per la valutazione neurofisiologica funzionamento correlati agli interventi terapeutici nel trattamento delle malattie neuropsichiatriche come depressione maggiore.

Questo metodo può aiutare a rispondere a domande chiave nei campi della neurologia, della neurofisiologia clinica e della psichiatria determinando i segnali neurofisiologici che possono fungere da predittori di risposta agli interventi terapeutici. Se eseguita correttamente, questa tecnica può monitorare, in modo affidabile e riproducibile, i cambiamenti nell'eccitabilità corticale dovuti a questi interventi terapeutici. A dimostrare la procedura sarà Stacey Shim, analista di ricerca del nostro laboratorio.

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