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Osteoarthritis Pain Model Induced by Intra-Articular Injection of Mono-Iodoacetate in Rats

Article DOI: 10.3791/60649-v • 08:09 min • May 20th, 2020
May 20th, 2020 •
1,2, 1,2, 1,2, 1, 1, 1
1The First Affiliated Hospital, Zhejiang Chinese Medical University, 2College of Pharmaceutical Science, Zhejiang Chinese Medical University

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This study describes the method of intra-articular injection of mono-iodoacetate in rats and discusses the resulting pain-related behaviors and histopathological changes, which provide references for future applications.

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Osteoarthritis Pain Model Intra-articular Injection Mono-iodoacetate Rats Pain-related Behavior Modeling Success Reproducible Procedure Time Efficiency Dose Acceleration Zuxiang Chen Supine Position Knee Fur Removal Disinfection With Alcohol Patella Tendon 26 Gauge Needle Insertion MIA Solution Injection Gauze Wrapping Reflux And Leakage Minimization Post-injection Time Points Elevated Plastic Container Wire Mesh Base Quiet Environment Adaptation Period Von Frey Needle Pressure
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