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Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
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Biologia
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JoVE Journal Biologia
Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations

4,249 Views

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11:15 min

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July 24, 2021

DOI:

10.3791/62311-v

DOI:
10.3791/62311-v

•

11:15 min
July 24, 2021

•

13 Views
, ,
1Faculty of Medicine and Medical Sciences,University of Balamand, 2Department of Clinical Microbiology,Michigan Health Clinics, 3College of Medicine,Central Michigan University

Summary

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This protocol describes how to study all possible combinations that can be obtained between four drugs in one single experiment. This method is based on the standard 96-well plate micro dilution assay and the calculation of fractional inhibitory concentrations (FICs) to evaluate the results.

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Cite this Article

Isber, C., Stockman, D. L., Daoud, Z. Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations. J. Vis. Exp. (173), e62311, doi:10.3791/62311 (2021).

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