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Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Article DOI: 10.3791/62560-v • 07:57 min • March 24th, 2022
March 24th, 2022 •
1, 1, 2, 3, 3, 2, 1
1Department of Diagnostic Sciences, Ghent University, 2Department of Electronics and Information Systems, Ghent University, 3Department of Head and Skin, Ghent University

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Here we present a protocol to perform preclinical positron emission tomography-based radiotherapy in a rat glioblastoma model using algorithms developed in-house to optimize the accuracy and efficiency.

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Positron Emission Tomography Dose Painting Radiation Therapy Glioblastoma Rat Model Small Animal Radiation Research Platform Preclinical PET-based Radiotherapy F98 Glioblastoma Rat Fluorine-18 FET Saline Injection PET Acquisition MRI PET Agent Multi-modality Bed Hook And Loop Fasteners Bubble Wrap PET Scan Reconstruction Voxel Size Maximum Likelihood Expectation Maximization Algorithm MRI Contrast Agent
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