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Sonodynamic Therapy for the Treatment of Glioblastoma Multiforme in a Mouse Model Using a Portable Benchtop Focused Ultrasound System

Article DOI: 10.3791/65114-v • 09:07 min • February 10th, 2023
February 10th, 2023 •
1,2, 1,2, 3, 1,2, 4, 1, 1, 5, 1, 1,2,4,6,7
1Department of Neurosurgery, Johns Hopkins University School of Medicine, 2Department of Biomedical Engineering, Johns Hopkins University, 3Krieger School of Arts and Sciences, Johns Hopkins University, 4Department of Electrical Engineering and Computer Science, Johns Hopkins University, 5Department of Radiology, Cancer Imaging Division, Johns Hopkins University School of Medicine, 6Department of Mechanical Engineering, Johns Hopkins University, 7Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine

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Here, we describe a protocol that details how to perform sonodynamic therapy in an in vivo mouse glioblastoma model using magnetic resonance-guided focused ultrasound.

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Sonodynamic Therapy Glioblastoma Multiforme Mouse Model Focused Ultrasound System Sonosensitizing Agent Increased Sensitivity Clinical Treatments Long-term Survival Rates Noninvasive Treatment Tumor-specific Treatment Sonosensitizers Reactive Oxidative Species Apoptosis Standardized Parameters Preclinical Studies Therapeutic Strategy Optimization Preclinical GBM Rodent Model Magnetic Resonance-guided FUS (MRgFUS) Specific Targeting Brain Tumor Benchtop Device
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