Un modello murino standardizzato con un flusso di lavoro a tre persone per studiare il rifiuto acuto cellulare e mediato dagli anticorpi nella xenotrapiantialità

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08:42 min.

20 marzo 2026

293 visualizzazioni

Xiaofei Zhu¹^,² , Jian Huang²^,³ , Yuqi An³^,⁴ , Peiyuan Li²^,³^,⁵ , Kai Xing²^,³^,⁵ , Yuan Chang²^,³^,⁵ , Jiangping Song²^,³^,⁵^,⁶^,⁷^,⁸

¹Department of Urology, Beijing Jishuitan Hospital Affiliated to Capital Medical University, ²Beijing Key Laboratory of Organ Xenotransplantation, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, ³State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, ⁴First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, ⁵Department of Cardiac Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, ⁶Department of Cardiac Surgery, Fuwai Yunnan Hospital, Chinese Academy of Medical Sciences, Affiliated Cardiovascular Hospital of Kunming Medical University, ⁷Shenzhen Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences, ⁸Sanya Institute of China Agricultural University

Questo studio stabilisce due modelli standardizzati di xenotrapianto murino per replicare specificamente il rigetto cellulare acuto e il rigetto acuto mediato da anticorpi. Questi modelli rappresentano una piattaforma affidabile per indagare i meccanismi del rigetto immunitario degli xenotrapianti, valutare strategie immunosoppressive e far progredire la ricerca preclinica sugli xenotrapianti.