Name: Approccio chirurgico allapprovvigionamento completo di allograft facciale dei tessuti molli per lallotrapianto composito vascolarizzato (Video) | JoVE Journal
Uploaded: 2025-12-30T14:33:00.000+00:00
Duration: 9 min 14 s
Description: Scopri la tecnica chirurgica per l'approvvigionamento completo di allograft facciale nei pazienti con gravi deformità. Questo protocollo standardizzato preserva i peduncoli vascolari e neurali per trapianti sicuri.

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<li>Von Arx, T., Tamura, K., Yukiya, O., Lozanoff, S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((The+face+-+a+vascular+perspective.+A+literature+review%5BTitle%5D)+AND+%22Swiss+Dent+J%22%5BJournal%5D)">The face - a vascular perspective. A literature review.</a> Swiss Dent J. 128 (5), 382-392 (2018).</li>
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<li>Swanson, J. W., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((The+retroauricular+approach+to+the+facial+nerve+trunk%5BTitle%5D)+AND+%22J+Craniofac+Surg%22%5BJournal%5D)">The retroauricular approach to the facial nerve trunk.</a> J Craniofac Surg. 28 (2), 347-351 (2017).</li>
<li>Von Arx, T., Abdelkarim, A. Z., Lozanoff, S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((The+face+-+a+neurosensory+perspective%5BTitle%5D)+AND+%22Swiss+Dent+J%22%5BJournal%5D)">The face - a neurosensory perspective.</a> Swiss Dent J. 127 (12), 1066-1075 (2017).</li>
<li>Frautschi, R., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Management+of+the+salivary+glands+and+facial+nerve+in+face+transplantation%5BTitle%5D)+AND+%22Plast+Reconstr+Surg%22%5BJournal%5D)">Management of the salivary glands and facial nerve in face transplantation.</a> Plast Reconstr Surg. 137 (6), 1887-1897 (2016).</li>
<li>Lee, S. H., Ha, T. J., Koh, K. S., Song, W. C. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((External+and+internal+diameters+of+the+facial+artery+relevant+to+intravascular+filler+injection%5BTitle%5D)+AND+%22Plast+Reconstr+Surg%22%5BJournal%5D)">External and internal diameters of the facial artery relevant to intravascular filler injection.</a> Plast Reconstr Surg. 143 (4), 1031-1037 (2019).</li>
<li>Koziej, M., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((The+superficial+temporal+artery%3A+A+meta-analysis+of+its+prevalence+and+morphology%5BTitle%5D)+AND+%22Clin+Anat%22%5BJournal%5D)">The superficial temporal artery: A meta-analysis of its prevalence and morphology.</a> Clin Anat. 33 (8), 1130-1137 (2020).</li>
<li>Wang, D., Xiong, S., Zeng, N., Wu, Y. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((The+facial+vein+on+computed+tomographic+angiography%3A+Implications+for+plastic+surgery+and+filler+injection%5BTitle%5D)+AND+%22Aesthet+Surg+J%22%5BJournal%5D)">The facial vein on computed tomographic angiography: Implications for plastic surgery and filler injection.</a> Aesthet Surg J. 42 (5), Np319-np326 (2022).</li>
<li>Freitas, C. aF., Santos, L., Santos, A. N., Amaral Neto, A. B. D., Brandão, L. G. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Anatomical+study+of+jugular+foramen+in+the+neck%5BTitle%5D)+AND+%22Braz+J+Otorhinolaryngol%22%5BJournal%5D)">Anatomical study of jugular foramen in the neck.</a> Braz J Otorhinolaryngol. 86 (1), 44-48 (2020).</li>
<li>Rusu, M. C., Tudose, R. C., Vrapciu, A. D., Toader, C., Popescu, ŞA. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Anatomical+variations+of+the+external+jugular+vein%3A+A+pictorial+and+critical+review%5BTitle%5D)+AND+%22Medicina+%28Kaunas%29%22%5BJournal%5D)">Anatomical variations of the external jugular vein: A pictorial and critical review.</a> Medicina (Kaunas). 59 (3), (2023).</li>
<li>Salame, K., Ouaknine, G. E., Arensburg, B., Rochkind, S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Microsurgical+anatomy+of+the+facial+nerve+trunk%5BTitle%5D)+AND+%22Clin+Anat%22%5BJournal%5D)">Microsurgical anatomy of the facial nerve trunk.</a> Clin Anat. 15 (2), 93-99 (2002).</li>
<li>Tong, J. Y., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Normative+data+for+dimensions+of+the+frontal+and+infraorbital+nerves%5BTitle%5D)+AND+%22Eye+%28Lond%29%22%5BJournal%5D)">Normative data for dimensions of the frontal and infraorbital nerves.</a> Eye (Lond). 39 (7), 1390-1393 (2025).</li>
<li>Pomahac, B., Pribaz, J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Facial+composite+tissue+allograft%5BTitle%5D)+AND+%22J+Craniofac+Surg%22%5BJournal%5D)">Facial composite tissue allograft.</a> J Craniofac Surg. 23 (1), 265-267 (2012).</li>
<li>Siemionow, M., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Coronal-posterior+approach+for+face%2Fscalp+flap+harvesting+in+preparation+for+face+transplantation%5BTitle%5D)+AND+%22J+Reconstr+Microsurg%22%5BJournal%5D)">Coronal-posterior approach for face/scalp flap harvesting in preparation for face transplantation.</a> J Reconstr Microsurg. 22 (6), 399-405 (2006).</li>
<li>Smeets, R., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Face+transplantation%3A+On+the+verge+of+becoming+clinical+routine%5BTitle%5D)+AND+%22Biomed+Res+Int%22%5BJournal%5D)">Face transplantation: On the verge of becoming clinical routine.</a> Biomed Res Int. 2014, 907272(2014).</li>
<li>Siemionow, M., Gharb, B. B., Rampazzo, A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Pathways+of+sensory+recovery+after+face+transplantation%5BTitle%5D)+AND+%22Plast+Reconstr+Surg%22%5BJournal%5D)">Pathways of sensory recovery after face transplantation.</a> Plast Reconstr Surg. 127 (5), 1875-1889 (2011).</li>
<li>Sosin, M., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Total+face%2C+eyelids%2C+ears%2C+scalp%2C+and+skeletal+subunit+transplant%3A+A+reconstructive+solution+for+the+full+face+and+total+scalp+burn%5BTitle%5D)+AND+%22Plast+Reconstr+Surg%22%5BJournal%5D)">Total face, eyelids, ears, scalp, and skeletal subunit transplant: A reconstructive solution for the full face and total scalp burn.</a> Plast Reconstr Surg. 138 (1), 205-219 (2016).</li>
<li>Perraudin, T., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Vascularized+composite+upper+limb+allograft+harvesting+for+proximal+arm+allotransplantation%5BTitle%5D)+AND+%22J+Vis+Exp%22%5BJournal%5D)">Vascularized composite upper limb allograft harvesting for proximal arm allotransplantation.</a> J Vis Exp. (220), e68170(2025).</li>
<li>Perraudin, T., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Vascularized+composite+hand+allograft+procurement+and+preparation+for+distal+and+proximal+forearm+allotransplantation%3A+A+stepwise+approach%5BTitle%5D)+AND+%22J+Vis+Exp%22%5BJournal%5D)">Vascularized composite hand allograft procurement and preparation for distal and proximal forearm allotransplantation: A stepwise approach.</a> J Vis Exp. (219), e67767(2025).</li>
<li>Barbat, P., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Procurement+for+a+vascularized+and+reinnervated+abdominal+wall+allotransplantation%5BTitle%5D)+AND+%22J+Vis+Exp%22%5BJournal%5D)">Procurement for a vascularized and reinnervated abdominal wall allotransplantation.</a> J Vis Exp. (221), e68418(2025).</li>
<li>Pomahac, B., Bueno, E. M., Sisk, G. C., Pribaz, J. J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Current+principles+of+facial+allotransplantation%3A+The+brigham+and+women%27s+hospital+experience%5BTitle%5D)+AND+%22Plast+Reconstr+Surg%22%5BJournal%5D)">Current principles of facial allotransplantation: The brigham and women's hospital experience.</a> Plast Reconstr Surg. 131 (5), 1069-1076 (2013).</li>
<li>Gurunian, R., Rampazzo, A., Papay, F., Gharb, B. b <a target="_blank" href="http://scholar.google.com/scholar?hl=en&safe=off&q=author%3aGurunian%2C+R+%22Reconstructive+transplantation%22">Reconstructive transplantation</a>. , Springer. Nature, Switzerland. (2023).</li>
<li>Pomahac, B., Gobble, R. M., Schneeberger, S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Facial+and+hand+allotransplantation%5BTitle%5D)+AND+%22Cold+Spring+Harb+Perspect+Med%22%5BJournal%5D)">Facial and hand allotransplantation.</a> Cold Spring Harb Perspect Med. 4 (3), a015651(2014).</li>
<li>Lupon, E., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((A+new+method+for+preparation+of+decellularized+human+scaffolds+for+facial+reconstruction%5BTitle%5D)+AND+%22Curr+Issues+Mol+Biol%22%5BJournal%5D)">A new method for preparation of decellularized human scaffolds for facial reconstruction.</a> Curr Issues Mol Biol. 47 (4), 275(2025).</li>
<li>Julienne, A., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((flap+harvest+training+on+a+new+ultrarealistic+simulation+model%3A+In-training+operator+feedback+about+a+pulsating+reperfused+and+reventilated+cadaver+simlife%C2%AE%5BTitle%5D)+AND+%22Ann+Chir+Plast+Esthet%22%5BJournal%5D)">flap harvest training on a new ultrarealistic simulation model: In-training operator feedback about a pulsating reperfused and reventilated cadaver simlife®.</a> Ann Chir Plast Esthet. 66 (2), 126-133 (2021).</li>
<li>Rodríguez-Lorenzo, A., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Vascular+perfusion+of+the+facial+skin%3A+Implications+in+allotransplantation+of+facial+aesthetic+subunits%5BTitle%5D)+AND+%22Plast+Reconstr+Surg%22%5BJournal%5D)">Vascular perfusion of the facial skin: Implications in allotransplantation of facial aesthetic subunits.</a> Plast Reconstr Surg. 138 (5), 1073-1079 (2016).</li>
<li>Quilichini, J., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Restoration+of+the+donor+after+face+graft+procurement+for+allotransplantation%3A+Report+on+the+technique+and+outcomes+of+seven+cases%5BTitle%5D)+AND+%22Plast+Reconstr+Surg%22%5BJournal%5D)">Restoration of the donor after face graft procurement for allotransplantation: Report on the technique and outcomes of seven cases.</a> Plast Reconstr Surg. 129 (5), 1105-1111 (2012).</li>
<li>Baker, C. E., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Pretreatments+of+ex+vivo+vascularized+composite+allografts%3A+A+scoping+review%5BTitle%5D)+AND+%22Ann+Plast+Surg%22%5BJournal%5D)">Pretreatments of ex vivo vascularized composite allografts: A scoping review.</a> Ann Plast Surg. , (2025).</li>
<li>Njessi, P., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Preservation+strategies+for+vascularized+composite+allotransplantation%3A+An+updated+systematic+review+of+a+rapidly+expanding+field%5BTitle%5D)+AND+%22bioRxiv%22%5BJournal%5D)">Preservation strategies for vascularized composite allotransplantation: An updated systematic review of a rapidly expanding field.</a> bioRxiv. , (2025).</li>
<li>Lupon, E., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((An+experimental+human+diep+flap+model+to+investigate+preservation+strategies+for+vascularized+composite+allografts+and+free+flaps%5BTitle%5D)+AND+%22J+Vis+Exp%22%5BJournal%5D)">An experimental human diep flap model to investigate preservation strategies for vascularized composite allografts and free flaps.</a> J Vis Exp. (226), e69392(2025).</li>
<li>Lupon, E., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Engineering+vascularized+composite+allografts+using+natural+scaffolds%3A+A+systematic+review%5BTitle%5D)+AND+%22Tissue+Eng+Part+B+Rev%22%5BJournal%5D)">Engineering vascularized composite allografts using natural scaffolds: A systematic review.</a> Tissue Eng Part B Rev. , (2021).</li>
</ol>

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approccio chirurgico all'approvvigionamento completo di allograft facciale dei tessuti molli per l'allotrapianto composito vascolarizzato

Surgical Approach to Full Soft Tissue Face Allograft Procurement for Vascularized Composite Allotransplantation

Approccio chirurgico all'approvvigionamento completo di allograft facciale dei tessuti molli per l'allotrapianto composito vascolarizzato

Full facial vascularized composite allotransplantation (VCA) offers a reconstructive option for patients with severe facial disfigurement who cannot be ...

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Vascolarizzato Composite Allotransplantations (VCA) sono diventati una realtà clinica. Tuttavia, la vasta applicazione clinica di VCA è limitata dalla immunosoppressione multi-farmaco cronica. Gli autori presentano un modello animale grande affidabile e riproducibile per tradurre nuove strategie immunomodulatori che possono minimizzare o potenzialmente eliminare la necessità di immunosoppressione in VCA.

Un modificata eterotopica suina Hind Arto Trapianto Modello traslazionale vascolarizzato composito allotrapianto (VCA) La ricerca

L'alloinnesto in composito vascolarizzato offre benefici che alterano la vita ai riceventi trapianti, ma le cause biologiche del rigetto del trapianto e della vascolopatia restano poco comprese. Il modello chirurgico del roditore presentato qui offre un modello di trapianto riproducibile e clinicamente rilevante, permettendo ai ricercatori di valutare gli eventi di rigetto e le potenziali strategie terapeutiche per prevenirne l'insorgenza.

Modificato Eterotopic Hindarto Osteomyocutaneo flap modello nel ratto per traslazionale vascolarizzazione composito Allotransplantazione ricerca

Il presente protocollo descrive il modello di lembo fascio-cutaneo suino e il suo potenziale utilizzo nella ricerca sui tessuti compositi vascolarizzati.

Un modello affidabile di lembo fascio-cutaneo suino per studi di bioingegneria di allotrapianti compositi vascolarizzati

Il protocollo descrive l'approvvigionamento chirurgico e la successiva decellularizzazione dei lembi suini vascolarizzati mediante la perfusione di detergente dodecilsolfato di sodio attraverso la vascolarizzazione del lembo in un bioreattore di perfusione personalizzato.

Approvvigionamento e perfusione-decellularizzazione di lembi vascolarizzati suini in un bioreattore di perfusione personalizzato

Descriviamo la tecnica chirurgica e il processo di decellularizzazione per gli arti posteriori compositi di ratto. La decellularizzazione viene condotta utilizzando dodecilsolfato di sodio a bassa concentrazione attraverso un sistema di perfusione ex vivo .

Approvvigionamento e decellularizzazione degli arti posteriori di ratto utilizzando un bioreattore ex vivo basato sulla perfusione per allotrapianto composito vascolarizzato

Qui, presentiamo un protocollo per l'approvvigionamento e la preparazione di allotrapianti di mano in composito vascolarizzato durante il trapianto di avambraccio distale o prossimale.

Approvvigionamento e preparazione dell'allotrapianto di mano in composito vascolarizzato per l'allotrapianto di avambraccio distale e prossimale: un approccio graduale

Qui, il protocollo spiega passo dopo passo la tecnica di prelievo di un allotrapianto della parte superiore del braccio a livello trans omerale o gleno-omerale durante un allotrapianto del braccio.

Prelievo di allotrapianto di arto superiore in composito vascolarizzato per l'allotrapianto del braccio prossimale

Questo protocollo descrive una procedura passo-passo per il prelievo di un alloinnesto di parete addominale vascolarizzato e reinnervato, descrivendone in dettaglio i punti di riferimento anatomici, i requisiti tecnici e le future potenziali applicazioni cliniche.

Acquisizione di un allotrapianto di parete addominale vascolarizzata e reinnervata

Questo protocollo descrive la tecnica chirurgica per il prelievo di un modello di lembo perforatore umano basato sul pedicolo dell'arteria epigastrica inferiore profonda, destinato alla ricerca sperimentale.

Un modello sperimentale di lembo DIEP umano per indagare strategie di conservazione per allografi compositi vascolarizzati e lembi liberi

Presentiamo un modello murino riproducibile di allotrapianto composito vascolarizzato eterotopo da arto posteriore a collo. Questo protocollo supermicrochirurgico, che prevede anastomosi vasali da 0,3-0,5 mm, integra la guida del filamento di nylon e la cuffia venosa. Fornisce una piattaforma affidabile per studi traslazionali su tolleranza, lesioni ischemiche-reperfusione e meccanismi immunologici nell'allotrapiante composito vascolarizato.

Trapianto eterotopico da arto posteriore a collo nel topo: un modello supermicrochirurgico di allotrapianto composito vascolarizzato

Scopri la tecnica chirurgica per l'approvvigionamento completo di allograft facciale nei pazienti con gravi deformità. Questo protocollo standardizzato preserva i peduncoli vascolari e neurali per trapianti sicuri.

Approccio chirurgico allapprovvigionamento completo di allograft facciale dei tessuti molli per lallotrapianto composito vascolarizzato (Video) | JoVE Journal

Approccio chirurgico all'approvvigionamento completo di allograft facciale dei tessuti molli per l'allotrapianto composito vascolarizzato

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