Automated Dispenser
Automated Dispenser - Related Videos
08:06
Automated Acoustic Dispensing for the Serial Dilution of Peptide Agonists in Potency Determination Assays
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Cited by 1 •
2016
Peptide adsorption to plasticware during traditional tip-based serial dilutions can significantly impact potency determination and confound the understanding of structure-activity relationships used for lead identification and lead optimization phases of drug discovery. Here methods for automated acoustic non-contact serial dilution of peptide samples are described.
10:14
Automated Robotic Dispensing Technique for Surface Guidance and Bioprinting of Cells
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Cited by 9 •
2016
This protocol describes a bioprinting methodology using an automated robotic depositing system that incorporates etched topographical guidance cues with the precision deposition of a cell bearing hydrogel bioink. The printed cells are directly delivered to the etched features and are able to sense and orientate with them.
07:05
Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer
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Cited by 6 •
2015
A Cartesian bioprinter was designed and fabricated to allow multi-material deposition in precise, reproducible geometries, while also allowing control of environmental factors. Utilizing the three-dimensional bioprinter, complex and viable constructs may be printed and easily reproduced.
10:36
Prescribed 3-D Direct Writing of Suspended Micron/Sub-micron Scale Fiber Structures via a Robotic Dispensing System
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Cited by 6 •
2015
Here, we present a protocol to fabricate freely-suspended, micron/sub-micron scale polymer fibers and “web-like” structures generated via automated direct writing procedure by means of a 3-axis dispensing system.
10:55
Digital Microfluidics for Automated Proteomic Processing
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Cited by 30 •
2009
Digital Microfluidics is a technique characterized by the manipulation of discrete droplets (~nL - mL) on an array of electrodes by the application of electrical fields. It is well-suited for carrying out rapid, sequential, miniaturized automated biochemical assays. Here, we report a platform capable of automating several proteomic processing steps.
FAQs
Accuracy depends on the coordinated action of calibrated pumps, valves, or robotic pipetting systems. Calibration links the commanded volume to the amount delivered, while programmed destinations and timing determine where and when each addition occurs. This coordination is especially important when the same reagent must be distributed across many wells, because consistent delivery supports comparable reaction conditions.
Volume settings specify how much reagent is transferred, destination settings identify the receiving vessel or well, and timing settings control when additions occur. Together, they provide a repeatable delivery plan for reaction mixtures, serial dilutions, and plate-based assays. Errors in any one setting can change reagent proportions, well assignments, or the sequence of additions, affecting comparability across samples.
Compared with manual handling, automation reduces operator variability and processing time by applying the same programmed instructions across samples. It also reduces repeated hands-on transfers, which helps maintain consistent reagent delivery and can conserve reagents. The main value is not simply speed: standardized execution makes results from large, systematically organized sample sets easier to compare.
A typical workflow begins by specifying reagent volumes, destinations, and timing in the instrument program. The system then uses its pump, valve, or robotic pipetting mechanism to aspirate the selected liquid and dispense it into designated vessels, often across a microplate. The programmed sequence can be repeated for many samples, creating consistent reaction setup or dilution steps.
In biochemistry, the instrument can prepare reaction mixtures for enzyme activity or binding studies, as well as generate serial dilutions. These applications require controlled distribution of reagents among many samples or wells. Automating the additions supports high-throughput assay formats, allowing investigators to process larger sample sets while preserving a planned relationship between volumes and destinations.
The resulting measurements can be interpreted across a structured set of samples because each receives additions according to the same programmed scheme. For enzyme activity and binding assays, consistent preparation helps connect observed assay differences to the samples or reaction conditions being studied rather than to changing manual delivery. This supports systematic analysis while reducing processing time and reagent consumption.