Ethanol Ablation
Ethanol Ablation - Related Videos
08:16
X-ray Visualization of Intraductal Ethanol-based Ablative Infusion for Prevention of Breast Cancer in Rabbit Models
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2025
This protocol presents a procedure for image-guided infusion into the ductal tree system of the rabbit mammary gland. We demonstrate controlled infusion of an X-ray contrast agent-containing ethanol-based ablative solution into all teat openings by fluoroscopy real-time imaging.
10:11
Microdialysis of Ethanol During Operant Ethanol Self-administration and Ethanol Determination by Gas Chromatography
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Cited by 13 •
2012
A method to determine the time course of ethanol concentration in the brains of rats during operant ethanol self-administration is described. Gas chromatography with flame ionization detection is used to quantify ethanol in the dialysate samples, because it has the sensitivity required for the small volumes that are generated.
11:21
Robotic Ablation of Atrial Fibrillation
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Cited by 12 •
2015
Pulmonary vein isolation (PVI) with an ablation catheter is a curative treatment for atrial fibrillation (AF). Robotic catheter systems aim to improve catheter steerability. Here, a procedure with a new robotic catheter system is presented. The goal of the procedure is electrical block between pulmonary vein and left atrium.
12:57
X-Ray Visualization of Intraductal Ethanol-Based Ablative Treatment for Prevention of Breast Cancer in Rat Models
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Cited by 2 •
2022
A procedure for the delivery of a chemical ablative solution to the rat mammary ductal tree for image-guided preventive treatment of breast cancer is described. Mammary epithelial cells can be targeted with minimal collateral tissue damage through cannulation directly into the nipple opening and intraductal infusion of a 70% ethanol-based ablative solution.
04:42
Targeted Neuronal Ablation Using Two-Photon Microscopy in a Zebrafish Larava
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2025
Source: Muto, A., et al. Ablation of a Neuronal Population Using a Two-photon Laser and Its Assessment Using Calcium Imaging and Behavioral Recording in Zebrafish Larvae. J. Vis. Exp. (2018) In this video, a two-photon laser ablation procedure is demonstrated, enabling the selective destruction of fluorescent neurons in agarose-immobilized zebrafish larvae. High-resolution imaging before and after the procedure confirms efficient neuronal damage, as observed by the absence of fluorescence.
FAQs
Ethanol damages targeted cancer tissue through several linked effects. It disrupts cell membranes, extracts lipids, denatures proteins, and dehydrates cells. These changes culminate in coagulative necrosis, while injury to small blood vessels can reduce the lesion’s blood supply. Considering both direct cellular injury and vascular effects helps researchers interpret treatment response.
Injection volume and ethanol distribution are central variables because treatment depends on where the agent reaches within a lesion. Researchers therefore assess whether the injected volume produces adequate coverage and how distribution relates to response. These measurements support efforts to improve procedural precision and explain incomplete treatment or later recurrence.
It is investigated as a localized option that may complement, rather than automatically replace, these approaches. Its relevance is greatest when surgery is unsuitable or unnecessary, while research examines when local ethanol treatment can fit alongside surgery, thermal ablation, or systemic therapy for localized malignancies.
The procedure centers on image-guided delivery of concentrated ethanol directly into the lesion. Research attention then turns to injection volume, the resulting ethanol distribution, and evidence of treatment response. This workflow links placement with measurable outcomes, allowing investigators to refine targeting and assess whether the treated region has been adequately addressed.
It has been applied most often to selected liver tumors and has also been investigated for other localized malignancies. The approach is particularly relevant when surgery is unsuitable or unnecessary, making lesion selection an important part of determining where a local treatment strategy may fit.
Cancer researchers evaluate treatment response and recurrence to determine how well the local intervention performs over time. These endpoints move assessment beyond whether ethanol was injected: investigators also ask whether the lesion responded and whether disease returned. Findings can clarify how the approach might complement surgery, thermal ablation, or systemic therapy.