Elevated Blood Pressure

Elevated blood pressure is a measurement of blood exerting greater-than-expected force against artery walls, making it an important clinical indicator of cardiovascular health. Blood pressure reflects cardiac output and systemic vascular resistance, which are influenced by vessel stiffness, fluid balance, and regulation by the sympathetic nervous system and renin-angiotensin-aldosterone system. Clinicians assess it through repeated measurements because readings can vary with activity, stress, and measurement conditions. Identifying persistent elevation supports timely lifestyle counseling, monitoring, and treatment to reduce the risk of heart disease, stroke, kidney damage, and other complications.

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Research

JoVE EoE - Neuropathology

Induction of Elevated Intraocular Pressure in a Rat Model

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2025

Source: Lani-Louzada, R., et al., Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents. J. Vis. Exp. (2022)This video demonstrates the induction and monitoring of elevated intraocular pressure (IOP) in a rat model. The process involves cauterizing the limbal blood vessels, resulting in vessel occlusion and elevated IOP. The rat is then allowed to recover, and IOP is regularly monitored in both the experimental and control eyes for comparison.

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye

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Cited by 7 •

2015

Trabecular meshwork (TM) migration into Schlemm’s canal space can be induced by acute pressure elevation by ophthalmodynamometer, and observed by spectral domain optical coherence tomography. The goal of this method is to quantify the morphometric response of the living outflow tract to acute pressure elevation in living tissues in situ.

Education

JoVE Science Education - Engineering

Noninvasive Blood Pressure Measurement Techniques

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2023

Source: Hamna J. Qureshi and Craig J. Goergen, Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana Here we will highlight the key similarities and differences of noninvasive blood pressure measurement techniques between humans and rodents and examine the engineering principles that govern blood pressure. The principles that govern current cuff technology to acquire systolic and diastolic pressures will also be discussed. Commercially available cuffs that connect...

Blood Pressure

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2024

The movement of blood in a human body, commonly referred to as blood flow, is determined by the volume of blood that traverses a certain section of the bodily system per unit time. It is the rhythmic contraction of the heart's ventricles that primarily instigates this movement. As the ventricles contract, blood is forced into the prominent arteries, which then flow from areas of greater pressure to lower pressure areas. This movement continues into smaller arteries and arterioles and...

Blood Pressure

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2024

Blood pressure (BP) is the pressure or force of blood exerted on the artery's walls as it circulates through the body. It is essential for maintaining blood flow throughout the body. The average BP in an adult is typically around 120/80 mmHg (millimeters of mercury). In this measurement, the numerator (120) indicates the systolic pressure, which is the pressure in the arteries during the contraction of the heart's ventricles as blood is expelled. The denominator (80) represents the diastolic...

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