Name: 肺癌の同系同所性マウスモデルを生成するための低侵襲法 (動画) | JoVE Journal
Uploaded: 2025-08-19T13:40:00.000+00:00
Duration: 7 min 46 s
Description: 学ぶ低侵襲法による肺癌の同系同所性マウスモデル生成プロトコル。バイオルミネセンスイメージングで早期腫瘍検出を実現し、腫瘍微小環境の研究や新規治療法の前臨床評価に貢献します。

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<li>Zhu, S., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Metabolomics+study+of+ribavirin+in+the+treatment+of+orthotopic+lung+cancer+based+on+UPLC-Q-TOF%2FMS%5BTitle%5D)+AND+%22Chem+Biol+Interact%22%5BJournal%5D)">Metabolomics study of ribavirin in the treatment of orthotopic lung cancer based on UPLC-Q-TOF/MS.</a> Chem Biol Interact. 370, 110305(2023).</li>
</ol>

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肺癌の同系同所性マウスモデルを生成するための低侵襲法

A Minimally Invasive Method for Generating a Syngeneic Orthotopic Mouse Model of Lung Cancer

Non-small cell lung cancer (NSCLC) continues to be the number one cause of cancer-related death for both women and men worldwide. More information needs ...

a-minimally-invasive-method-for-generating-syngeneic-orthotopic-mouse

Research

JoVE Journal

Cancer Research

がん研究

このビデオは、マウスモデルでの乳がんの同所性接種技術を示しています。この技術は、皮下注射または非外科的注射と比較して、腫瘍のサイズと形状のばらつきが少なく、高い腫瘍形成率を生み出します。...

同所性注射:成体マウスへの組織特異的がん細胞の移植

主な侵襲的同所性膀胱癌異種移植片を接種するために確立された技術は、開腹手術と膀胱の動員を必要とします。この手順では、マウスに有意な病的状態を負わせる技術的に困難であり、時間がかかる。したがって、我々は、経皮的アプローチは、超音波誘導を利用して、高精度を開発した。...

マウス同所性膀胱異種移植片の最小侵襲性の確立

癌の転移拡散は、癌関連死の主要な原因です。私たちは、固形臓器腫瘍で転移のメカニズムを研究するための「患者様」同所同系マウスモデル系を確立するための私たちの生存の手術方法の詳細な説明を提供します。...

肝細胞癌転移の「患者様」同所同系マウスモデル

私たちは、マイクロコンピュータ断層撮影法を用いて腺癌マウスモデルの肺における腫瘍結節の発生を検出する方法と、その使用を経時的な結節サイズの変化および治療に反応して監視するための方法について説明します。評価の精度は、エンドポイントの組織学的定量化によって確認されました。...

腫瘍の開発の評価のためのマイクロコンピュータ断層撮影を使用し、肺癌のマウスモデルでの治療に対する応答のフォローアップ

転移は癌の病原性に深い役割を果たしており、死亡者の推定90%を占めています。...

同系マウスメラノーマ細胞の注入は、肺におけるそれらの転移能を決定するために、

事前の負傷で気道をコンディショニングすることでマウスの肺に肺癌細胞の同所性同種移植を大幅に強化する手法について述べる。このアプローチは肺微小環境、転移播種、肺癌併存、間質相互作用の研究にも適用可能性があり、派生した異種移植片をより効率的に患者を生成します。...

同所性同種肺がん細胞生着の効率を高めるブレオマイシンとマウスの気道をプレコンディショニング

マウス実験乳房癌モデルと人間の胸の癌の進行を模倣する腫瘍負荷を定量化する発光技術と根治的乳房切除モデルを紹介しています。...

マウス実験転移性乳癌癌モデルを生成、およびマウス乳癌根治術を実行

ここで非小細胞肺癌を勉強する時間とコスト削減モデルとしてマウス肺腺癌細胞の低侵襲同系同所性同種移植モデルについて述べる。...

PD L1 の発現を研究する同系の肺腺癌細胞の同所性同種移植

本プロトコールは、同所性骨肉腫および肺転移病変を有するマウスモデルを生成するための脛骨内骨肉腫細胞注射を記載する。...

同所性骨肉腫および肺転移マウスモデルを生成するための脛骨内骨肉腫細胞注射

この研究は、蛍光A549-iRFP細胞の多細胞スフェロイドの肺内接種に基づく同所性非小細胞肺がん(NSCLC)モデルを示しています。このモデルは、長波長蛍光の動的 in vivo モニタリングに従って、臨床NSCLC病期を再現し、シスプラチンに応答します。...

疾患進行を模倣し薬物活性を予測する非小細胞肺癌の同所性異種移植モデルの構築

学ぶ低侵襲法による肺癌の同系同所性マウスモデル生成プロトコル。バイオルミネセンスイメージングで早期腫瘍検出を実現し、腫瘍微小環境の研究や新規治療法の前臨床評価に貢献します。

肺癌の同系同所性マウスモデルを生成するための低侵襲法

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