Name: 血管化複合体移植のための全身軟部組織顔面同種移植の外科的アプローチ (動画) | JoVE Journal
Uploaded: 2025-12-30T14:33:00.000+00:00
Duration: 9 min 14 s
Description: 学ぶ全身軟部組織顔面同種移植の外科的手法。血管・神経を保全しながら軟部組織を採取し、嚢状骨切り術と経口アプローチで顔面構造を確保する標準化プロトコル。

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5 minutes

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<li>Von Arx, T., Abdelkarim, A. Z., Lozanoff, S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((The+face+-+a+neurosensory+perspective%5BTitle%5D)+AND+%22Swiss+Dent+J%22%5BJournal%5D)">The face - a neurosensory perspective.</a> Swiss Dent J. 127 (12), 1066-1075 (2017).</li>
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<li>Lee, S. H., Ha, T. J., Koh, K. S., Song, W. C. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((External+and+internal+diameters+of+the+facial+artery+relevant+to+intravascular+filler+injection%5BTitle%5D)+AND+%22Plast+Reconstr+Surg%22%5BJournal%5D)">External and internal diameters of the facial artery relevant to intravascular filler injection.</a> Plast Reconstr Surg. 143 (4), 1031-1037 (2019).</li>
<li>Koziej, M., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((The+superficial+temporal+artery%3A+A+meta-analysis+of+its+prevalence+and+morphology%5BTitle%5D)+AND+%22Clin+Anat%22%5BJournal%5D)">The superficial temporal artery: A meta-analysis of its prevalence and morphology.</a> Clin Anat. 33 (8), 1130-1137 (2020).</li>
<li>Wang, D., Xiong, S., Zeng, N., Wu, Y. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((The+facial+vein+on+computed+tomographic+angiography%3A+Implications+for+plastic+surgery+and+filler+injection%5BTitle%5D)+AND+%22Aesthet+Surg+J%22%5BJournal%5D)">The facial vein on computed tomographic angiography: Implications for plastic surgery and filler injection.</a> Aesthet Surg J. 42 (5), Np319-np326 (2022).</li>
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<li>Pomahac, B., Pribaz, J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Facial+composite+tissue+allograft%5BTitle%5D)+AND+%22J+Craniofac+Surg%22%5BJournal%5D)">Facial composite tissue allograft.</a> J Craniofac Surg. 23 (1), 265-267 (2012).</li>
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<li>Smeets, R., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Face+transplantation%3A+On+the+verge+of+becoming+clinical+routine%5BTitle%5D)+AND+%22Biomed+Res+Int%22%5BJournal%5D)">Face transplantation: On the verge of becoming clinical routine.</a> Biomed Res Int. 2014, 907272(2014).</li>
<li>Siemionow, M., Gharb, B. B., Rampazzo, A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Pathways+of+sensory+recovery+after+face+transplantation%5BTitle%5D)+AND+%22Plast+Reconstr+Surg%22%5BJournal%5D)">Pathways of sensory recovery after face transplantation.</a> Plast Reconstr Surg. 127 (5), 1875-1889 (2011).</li>
<li>Sosin, M., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Total+face%2C+eyelids%2C+ears%2C+scalp%2C+and+skeletal+subunit+transplant%3A+A+reconstructive+solution+for+the+full+face+and+total+scalp+burn%5BTitle%5D)+AND+%22Plast+Reconstr+Surg%22%5BJournal%5D)">Total face, eyelids, ears, scalp, and skeletal subunit transplant: A reconstructive solution for the full face and total scalp burn.</a> Plast Reconstr Surg. 138 (1), 205-219 (2016).</li>
<li>Perraudin, T., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Vascularized+composite+upper+limb+allograft+harvesting+for+proximal+arm+allotransplantation%5BTitle%5D)+AND+%22J+Vis+Exp%22%5BJournal%5D)">Vascularized composite upper limb allograft harvesting for proximal arm allotransplantation.</a> J Vis Exp. (220), e68170(2025).</li>
<li>Perraudin, T., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Vascularized+composite+hand+allograft+procurement+and+preparation+for+distal+and+proximal+forearm+allotransplantation%3A+A+stepwise+approach%5BTitle%5D)+AND+%22J+Vis+Exp%22%5BJournal%5D)">Vascularized composite hand allograft procurement and preparation for distal and proximal forearm allotransplantation: A stepwise approach.</a> J Vis Exp. (219), e67767(2025).</li>
<li>Barbat, P., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Procurement+for+a+vascularized+and+reinnervated+abdominal+wall+allotransplantation%5BTitle%5D)+AND+%22J+Vis+Exp%22%5BJournal%5D)">Procurement for a vascularized and reinnervated abdominal wall allotransplantation.</a> J Vis Exp. (221), e68418(2025).</li>
<li>Pomahac, B., Bueno, E. M., Sisk, G. C., Pribaz, J. J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Current+principles+of+facial+allotransplantation%3A+The+brigham+and+women%27s+hospital+experience%5BTitle%5D)+AND+%22Plast+Reconstr+Surg%22%5BJournal%5D)">Current principles of facial allotransplantation: The brigham and women's hospital experience.</a> Plast Reconstr Surg. 131 (5), 1069-1076 (2013).</li>
<li>Gurunian, R., Rampazzo, A., Papay, F., Gharb, B. b <a target="_blank" href="http://scholar.google.com/scholar?hl=en&safe=off&q=author%3aGurunian%2C+R+%22Reconstructive+transplantation%22">Reconstructive transplantation</a>. , Springer. Nature, Switzerland. (2023).</li>
<li>Pomahac, B., Gobble, R. M., Schneeberger, S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Facial+and+hand+allotransplantation%5BTitle%5D)+AND+%22Cold+Spring+Harb+Perspect+Med%22%5BJournal%5D)">Facial and hand allotransplantation.</a> Cold Spring Harb Perspect Med. 4 (3), a015651(2014).</li>
<li>Lupon, E., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((A+new+method+for+preparation+of+decellularized+human+scaffolds+for+facial+reconstruction%5BTitle%5D)+AND+%22Curr+Issues+Mol+Biol%22%5BJournal%5D)">A new method for preparation of decellularized human scaffolds for facial reconstruction.</a> Curr Issues Mol Biol. 47 (4), 275(2025).</li>
<li>Julienne, A., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((flap+harvest+training+on+a+new+ultrarealistic+simulation+model%3A+In-training+operator+feedback+about+a+pulsating+reperfused+and+reventilated+cadaver+simlife%C2%AE%5BTitle%5D)+AND+%22Ann+Chir+Plast+Esthet%22%5BJournal%5D)">flap harvest training on a new ultrarealistic simulation model: In-training operator feedback about a pulsating reperfused and reventilated cadaver simlife®.</a> Ann Chir Plast Esthet. 66 (2), 126-133 (2021).</li>
<li>Rodríguez-Lorenzo, A., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Vascular+perfusion+of+the+facial+skin%3A+Implications+in+allotransplantation+of+facial+aesthetic+subunits%5BTitle%5D)+AND+%22Plast+Reconstr+Surg%22%5BJournal%5D)">Vascular perfusion of the facial skin: Implications in allotransplantation of facial aesthetic subunits.</a> Plast Reconstr Surg. 138 (5), 1073-1079 (2016).</li>
<li>Quilichini, J., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Restoration+of+the+donor+after+face+graft+procurement+for+allotransplantation%3A+Report+on+the+technique+and+outcomes+of+seven+cases%5BTitle%5D)+AND+%22Plast+Reconstr+Surg%22%5BJournal%5D)">Restoration of the donor after face graft procurement for allotransplantation: Report on the technique and outcomes of seven cases.</a> Plast Reconstr Surg. 129 (5), 1105-1111 (2012).</li>
<li>Baker, C. E., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Pretreatments+of+ex+vivo+vascularized+composite+allografts%3A+A+scoping+review%5BTitle%5D)+AND+%22Ann+Plast+Surg%22%5BJournal%5D)">Pretreatments of ex vivo vascularized composite allografts: A scoping review.</a> Ann Plast Surg. , (2025).</li>
<li>Njessi, P., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Preservation+strategies+for+vascularized+composite+allotransplantation%3A+An+updated+systematic+review+of+a+rapidly+expanding+field%5BTitle%5D)+AND+%22bioRxiv%22%5BJournal%5D)">Preservation strategies for vascularized composite allotransplantation: An updated systematic review of a rapidly expanding field.</a> bioRxiv. , (2025).</li>
<li>Lupon, E., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((An+experimental+human+diep+flap+model+to+investigate+preservation+strategies+for+vascularized+composite+allografts+and+free+flaps%5BTitle%5D)+AND+%22J+Vis+Exp%22%5BJournal%5D)">An experimental human diep flap model to investigate preservation strategies for vascularized composite allografts and free flaps.</a> J Vis Exp. (226), e69392(2025).</li>
<li>Lupon, E., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Engineering+vascularized+composite+allografts+using+natural+scaffolds%3A+A+systematic+review%5BTitle%5D)+AND+%22Tissue+Eng+Part+B+Rev%22%5BJournal%5D)">Engineering vascularized composite allografts using natural scaffolds: A systematic review.</a> Tissue Eng Part B Rev. , (2021).</li>
</ol>

<table><tbody><tr><td>11.5インチミディアムプレミアム Surgiclip II オートスーツ容器クリップアプリ</td><td>コロビディエン</td><td></td><td></td></tr><tr><td>2-0シルク縫合&nbsp;</td><td></td><td></td><td></td></tr><tr><td>アドソン鉗子</td><td>MPM</td><td>106-2112A</td><td></td></tr><tr><td>バイオインピーダンスドリル</td><td>ストライカー</td><td>5400-50</td><td>視道および頭蓋底の解剖用のバイオインピーダンスフィードバック付き高速ドリル</td></tr><tr><td>双極性凝固鉗子</td><td>オルセン</td><td>20-1320I</td><td></td></tr><tr><td>Custodiol HTK溶液 四肢灌流用</td><td>エッセンシャル・ファーマシューティカルズ社</td><td></td><td>適応外使用法</td></tr><tr><td>膀胱/膀胱洗浄セット&nbsp;</td><td>バクスター・ヘルスケア・コーポレーション</td><td></td><td></td></tr><tr><td>使い捨てメス #15</td><td>スカラー</td><td></td><td></td></tr><tr><td>DLP 3mm血管カニューレ鈍先端</td><td>メドトロニック社</td><td></td><td></td></tr><tr><td>鉗子拡張器</td><td>WPI</td><td>15910</td><td></td></tr><tr><td>IVストップコック</td><td></td><td></td><td></td></tr><tr><td>マイクロシザーズ</td><td>WPI</td><td>504492</td><td></td></tr><tr><td>モノポーラー・ダイアサーミー</td><td>バレーラブ</td><td></td><td></td></tr><tr><td>振動式のこぎり</td><td>ストライカー</td><td>5400-31</td><td>頭蓋顔面骨切開術用の標準的な振動ノコギリ(Synthes/DePuyも含む)</td></tr><tr><td>生理食塩水 0.9%</td><td>ジェンデポ</td><td>S0600-101</td><td></td></tr><tr><td>斜視はさみ</td><td>サーテックス</td><td>102-4109</td><td></td></tr><tr><td>サージカルマーキングペン</td><td>カーディナルヘルス</td><td>212PR</td><td></td></tr><tr><td>縫合エチロン 4.0</td><td>エティコン</td><td>1667G</td><td></td></tr><tr><td>縫合エチロン4.0および9.0</td><td>エティコン</td><td>1667G</td><td></td></tr><tr><td>シリンゲ 10ml</td><td>アジレント</td><td>9301-6474</td><td></td></tr><tr><td>滅菌の調達用ビニール袋が3つ、滅菌された結束バンドが3本</td><td></td><td></td><td></td></tr><tr><td>組織鉗子</td><td>MPM</td><td>106-0511</td><td></td></tr><tr><td>ウィスコンシン大学(UW)の臓器保存ソリューション</td><td>人生への橋</td><td></td><td>適応外使用法</td></tr><tr><td>船舶ループ</td><td>デロイヤル</td><td>30-711</td><td></td></tr></tbody></table>

血管化複合体移植のための全身軟部組織顔面同種移植の外科的アプローチ

Surgical Approach to Full Soft Tissue Face Allograft Procurement for Vascularized Composite Allotransplantation

Full facial vascularized composite allotransplantation (VCA) offers a reconstructive option for patients with severe facial disfigurement who cannot be ...

surgical-approach-to-full-soft-tissue-face-allograft-procurement-for

Research

JoVE Journal

Medicine

医学

血管化コンポジット同種移植（VCA）は、臨床現実のものとなっている。ただし、VCAの広範な臨床応用は、慢性多剤免疫抑制によって制限されます。著者らは、最小化または潜在的にVCAにおける免疫抑制の必要性を排除することができる新規免疫調節戦略を変換するために、信頼性と再現性のある大規模な動物モデルを提示する。...

トランスレーショナル血管柄コンポジット同種移植（VCA）研究用に修正異豚後肢移植モデル

血管化複合同種移植片は、移植患者に生命を変える利点を提供するが、移植片拒絶および vasculopathy...

トランスレーショナル血管化複合体他家移植研究のためのラットにおける修正 Heterotopic 後肢 Osteomyocutaneous フラップモデル

本プロトコルは、ブタ筋膜皮膚皮弁モデルおよび血管新生複合組織研究におけるその潜在的な使用について説明しています。...

血管化複合同種移植片バイオエンジニアリング研究のための信頼性の高いブタ筋膜皮膚フラップモデル

プロトコルは、カスタマイズされた灌流バイオリアクター内のフラップ血管系を介したドデシル硫酸ナトリウム界面活性剤の灌流による血管化ブタフラップの外科的調達とその後の脱細胞化について説明しています。...

カスタマイズされた灌流バイオリアクターにおけるブタ血管化フラップの調達と灌流-脱細胞化

複合ラット後肢の手術手技と脱細胞化プロセスについて説明します。脱細胞化は、 ex vivo マシン灌流システムを介して低濃度ドデシル硫酸ナトリウムを使用して行われます。...

血管化複合同種移植のための 生体外 灌流ベースのバイオリアクターを用いたラット後肢の調達と脱細胞化

ここでは、遠位または近位前腕移植中に血管新生複合ハンド同種移植片を調達および準備するためのプロトコルを紹介します。...

遠位および近位前腕同種移植のための血管新生複合手同種移植片の調達と準備:段階的アプローチ

ここでは、プロトコルは、腕の同種移植中に上腕骨または肩甲上腕骨レベルで上腕同種移植片を採取する技術を段階的に説明しています。...

近位腕同種移植のための血管新生複合上肢同種移植収穫

このプロトコルでは、血管新生および再神経支配された腹壁同種移植片を採取するための段階的な手順を説明し、その解剖学的ランドマーク、技術要件、および将来の潜在的な臨床応用について詳しく説明します。...

血管新生および再神経支配腹壁同種移植のための調達

このプロトコルは、実験研究を目的とした、深部下腹上動脈脚に基づくヒト穿孔皮弁モデルの外科的収穫技術を説明しています。...

血管化複合同種移植および遊離フラップの保存戦略を調査するための実験的ヒトDIEPフラップモデル

我々は、異所性後肢から首への血管化複合異種移植の再現可能なマウスモデルを提示します。この超顕微外科プロトコルは0.3〜0.5mmの血管吻合を含み、ナイロンフィラメント誘導と静脈カフを統合しています。この研究は、血管化複合型異種移植における寛容性、虚血再灌流損傷、免疫学的メカニズムに関する翻訳研究の信頼できるプラットフォームを提供します。...

マウスにおける異所性後肢から頸部への移植:血管化複合型アロ移植の超顕微外科モデル

学ぶ全身軟部組織顔面同種移植の外科的手法。血管・神経を保全しながら軟部組織を採取し、嚢状骨切り術と経口アプローチで顔面構造を確保する標準化プロトコル。

血管化複合体移植のための全身軟部組織顔面同種移植の外科的アプローチ

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