Name: 卵モデルにおける肺高血圧症右心室不全における構造化運動レジメン (動画) | JoVE Journal
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Description: 学ぶ肺高血圧症右心室不全の運動生理を羊モデルで。構造化運動レジメンにより右心室後負荷増加下での適応的代償メカニズムを評価し、治療戦略開発への知見を提供する。

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<li>Boucherat, O., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((The+latest+in+animal+models+of+pulmonary+hypertension+and+right+ventricular+failure%5BTitle%5D)+AND+%22Circ+Res%22%5BJournal%5D)">The latest in animal models of pulmonary hypertension and right ventricular failure.</a> Circ Res. 130 (9), 1466-1486 (2022).</li>
<li>Long, G., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Skeletal+muscle+blood+flow+during+exercise+is+reduced+in+a+rat+model+of+pulmonary+hypertension%5BTitle%5D)+AND+%22Am+J+Physiol%22%5BJournal%5D)">Skeletal muscle blood flow during exercise is reduced in a rat model of pulmonary hypertension.</a> Am J Physiol. 323 (4), R561-R570 (2022).</li>
<li>Rothman, A., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Challenges+in+the+development+of+chronic+pulmonary+hypertension+models+in+large+animals%5BTitle%5D)+AND+%22Pulm+Circ%22%5BJournal%5D)">Challenges in the development of chronic pulmonary hypertension models in large animals.</a> Pulm Circ. 7 (1), 156-166 (2017).</li>
<li>Stam, K., Clauss, S., Taverne, Y., Merkus, D. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Chronic+thromboembolic+pulmonary+hypertension%3A+what+have+we+learned+from+large+animal+models%5BTitle%5D)+AND+%22Front+Cardiovasc+Med%22%5BJournal%5D)">Chronic thromboembolic pulmonary hypertension: what have we learned from large animal models.</a> Front Cardiovasc Med. 8, 574360(2021).</li>
<li>Stam, K., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Exercise+facilitates+early+recognition+of+cardiac+and+vascular+remodeling+in+chronic+thromboembolic+pulmonary+hypertension+in+swine%5BTitle%5D)+AND+%22Am+J+Physiol%22%5BJournal%5D)">Exercise facilitates early recognition of cardiac and vascular remodeling in chronic thromboembolic pulmonary hypertension in swine.</a> Am J Physiol. 314 (3), H627-H642 (2017).</li>
<li>Stam, K., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Exercise+response+in+a+new+porcine+model+of+chronic+embolic+pulmonary+hypertension%5BTitle%5D)+AND+%22FASEB+J%22%5BJournal%5D)">Exercise response in a new porcine model of chronic embolic pulmonary hypertension.</a> FASEB J. 29 (S1), LB597(2015).</li>
<li>Morris, N., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Exercise-based+rehabilitation+programmes+for+pulmonary+hypertension%5BTitle%5D)+AND+%22Cochrane+Database+Syst+Rev%22%5BJournal%5D)">Exercise-based rehabilitation programmes for pulmonary hypertension.</a> Cochrane Database Syst Rev. 3 (3), CD011285(2023).</li>
<li>Rusakova, Y., Zhuravleva, I. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Functional+anatomy+of+the+sheep+heart+as+a+model+for+testing+cardiovascular+devices%5BTitle%5D)+AND+%22Sovrem+Tekhnol+Med%22%5BJournal%5D)">Functional anatomy of the sheep heart as a model for testing cardiovascular devices.</a> Sovrem Tekhnol Med. 17 (2), 13-22 (2025).</li>
<li>Divincenti, L., Westcott, R., Lee, C. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Sheep+%28Ovis+aries%29+as+a+model+for+cardiovascular+surgery+and+management+before%2C+during+and+after+cardiopulmonary+bypass%5BTitle%5D)+AND+%22J+Am+Assoc+Lab+Anim+Sci%22%5BJournal%5D)">Sheep (Ovis aries) as a model for cardiovascular surgery and management before, during and after cardiopulmonary bypass.</a> J Am Assoc Lab Anim Sci. 53 (5), 439-448 (2014).</li>
<li>Ukita, R., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Ambulatory+seven-day+mechanical+circulatory+support+in+sheep+model+of+pulmonary+hypertension+and+right+heart+failure%5BTitle%5D)+AND+%22J+Heart+Lung+Transplant%22%5BJournal%5D)">Ambulatory seven-day mechanical circulatory support in sheep model of pulmonary hypertension and right heart failure.</a> J Heart Lung Transplant. 43 (2), 293-302 (2025).</li>
<li>Heerdt, P., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Right+ventricular+pressure+waveform+analysis%3A+clinical+relevance+and+future+directions%5BTitle%5D)+AND+%22J+Cardiothorac+Vasc+Anesth%22%5BJournal%5D)">Right ventricular pressure waveform analysis: clinical relevance and future directions.</a> J Cardiothorac Vasc Anesth. 38 (10), 2433-2445 (2024).</li>
<li>Heerdt, P., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Integrating+right+ventricular+pressure+waveform+analysis+with+two-point+volume+measurement+for+quantification+of+systolic+and+diastolic+function%3A+experimental+validation+and+clinical+application%5BTitle%5D)+AND+%22J+Cardiothorac+Vasc+Anesth%22%5BJournal%5D)">Integrating right ventricular pressure waveform analysis with two-point volume measurement for quantification of systolic and diastolic function: experimental validation and clinical application.</a> J Cardiothorac Vasc Anesth. 37 (10), 1929-1937 (2023).</li>
</ol>

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卵モデルにおける肺高血圧症右心室不全における構造化運動レジメン

Structured Exercise Regimen in Pulmonary Hypertension-Right Ventricular Failure in an Ovine Model

Right heart failure (RHF) is a significant cause of morbidity and mortality from pulmonary hypertension (PH). To better understand the pathophysiology and ...

structured-exercise-regimen-pulmonary-hypertension-right-ventricular

Research

JoVE Journal

Medicine

医学

慢性血栓塞栓性肺高血圧症(CTEPH)と右心室(RV)機能障害は、肺動脈の進行性閉塞によって子豚に誘発されました。結果は、CTEPH患者で観察されたものと非常に類似していました。この動物モデルは、CTEPHおよびRV不全の病態生理学および治療実験に非常に有用なツールとなるでしょう。...

慢性血栓塞栓性肺高血圧症とピグレットにおける右室機能の評価

ここでは、豚の頻拍誘発型心筋症を生成するためのプロトコルを提案する.このモデルは、進行性の慢性心不全の血行動態や応用治療の効果を研究する強力な方法を表します。...

豚の慢性心不全モデルとして頻拍誘発性心筋

ARDS の大動物モデルで大動脈と肺動脈の血行動態の侵襲血行動態モニタリング

慢性肺高血圧症の大型動物モデルにおいて、急性右心不全を誘導し表現するプロトコルを提示する。このモデルは、治療介入をテストしたり、右心の指標を開発したり、急性右心不全病態生理学の理解を深めるために使用できます。...

慢性血栓塞栓性肺高血圧症の大型動物モデルにおける急性右心不全の誘導とフェノタイピング

ここでは、右心室不全のメカニズムを研究するための有用なアプローチを提供する。肺動脈収縮へのより便利で、有効なアプローチは、社内で作られた手術器具を使用して確立されます。さらに、心エコー検査およびカテーテル法によるこのアプローチの品質を評価する方法が提供される。...

肺動脈収縮による右心室障害の誘導とマウスにおける右心室機能の評価

ここでは、急性右心室機能障害を有するブタにおける入院ベースの両心室圧 -...

ブタモデルにおけるアドミタンスカテーテルによる閉鎖胸部両室圧容積ループ記録

この原稿は、それらの適応および不適応表現型をモデル化するために重度の右心室圧過負荷を発症させるための外科的技術および実験的アプローチを説明する。...

肺高血圧症と右心室不全の大型動物モデル:羊の左肺動脈結紮と進行性主肺動脈バンディング

本プロトコルは、肺動脈性肺高血圧症のラットモデルにおける右心室の形態および機能の心エコー検査の特徴付けを記載する。...

肺動脈性肺高血圧症ラットモデルにおける右心室機能の網羅的心エコー評価

右心室不全と機能性三尖弁逆流は、左側の心臓病と肺高血圧症に関連しており、患者の罹患率と死亡率に大きく寄与しています。右心室不全と機能性三尖弁逆流を研究するための慢性ヒツジモデルを確立することは、それらのメカニズム、進行、および可能な治療法を理解するのに役立ちます。...

右室不全と機能性三尖弁逆流の慢性ヒツジモデル

肺体幹バンディングによって誘発される右心室圧過負荷のマウスモデルについて説明します。この論文には、挿管、手術、および心エコー検査による表現型の詳細なプロトコルが含まれています。挿管や手術にはカスタムメイドの器具が使用されるため、モデルを迅速かつ安価に再現することができます。...

肺体幹バンディングによる圧力過負荷誘発右心室肥大と失敗のマウスモデル

右心室の機能を評価するための詳細な方法の提示は、肺高血圧症研究の品質と信頼性を向上させ、将来の研究のための強固なフレームワークを提供し、異なる研究室間での再現性を向上させます。...

肺動脈性肺高血圧症の実験モデルにおける右室機能の評価

学ぶ肺高血圧症右心室不全の運動生理を羊モデルで。構造化運動レジメンにより右心室後負荷増加下での適応的代償メカニズムを評価し、治療戦略開発への知見を提供する。

卵モデルにおける肺高血圧症右心室不全における構造化運動レジメン

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