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Pharmacokinetics and Pharmacodynamics

Video textbook for undergraduate courses: Visualized concepts and experiments

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13 Chapters

221 Videos

1,300+ Multiple Choice Questions

Chapter 1

Pharmacokinetics and Pharmacodynamics: Introduction

12 Videos · 15 Minutes

Biopharmaceutics and Pharmacokinetics: Overview

1.1: Biopharmaceutics and Pharmacokinetics: Overview

2.9K views

Pharmacokinetic Models: Overview

1.2: Pharmacokinetic Models: Overview

1.5K views

Drug Concentration Versus Time Correlation

1.3: Drug Concentration Versus Time Correlation

1.5K views

Drug Concentrations: Measurements

1.4: Drug Concentrations: Measurements

777 views

Fundamental Mathematical Principles in Pharmacokinetics: Calculus and Graphs

1.5: Fundamental Mathematical Principles in Pharmacokinetics: Calculus and Graphs

2.4K views

Fundamental Mathematical Principles in Pharmacokinetics: Mathematical Expressions and Units

1.6: Fundamental Mathematical Principles in Pharmacokinetics: Mathematical Expressions and Units

1.1K views

Fundamental Mathematical Principles in Pharmacokinetics: Rate and Order of Reaction

1.7: Fundamental Mathematical Principles in Pharmacokinetics: Rate and Order of Reaction

805 views

Analysis of Population Pharmacokinetic Data

1.8: Analysis of Population Pharmacokinetic Data

509 views

Pharmacodynamics: Overview and Principles

1.9: Pharmacodynamics: Overview and Principles

2.5K views

Structure-Activity Relationships and Drug Design

1.10: Structure-Activity Relationships and Drug Design

1.3K views

Agonism and Antagonism: Quantification

1.11: Agonism and Antagonism: Quantification

720 views

Drug Control Governance: Regulatory Bodies and Their Impact

1.12: Drug Control Governance: Regulatory Bodies and Their Impact

337 views

Chapter 2

Biostatistics: Introduction

10 Videos · 12 Minutes

Biostatistics: Overview

2.1: Biostatistics: Overview

449 views

Data: Types and Distribution

2.2: Data: Types and Distribution

982 views

Central Tendency: Analysis

2.3: Central Tendency: Analysis

285 views

Variability: Analysis

2.4: Variability: Analysis

249 views

Statistical Hypothesis Testing

2.5: Statistical Hypothesis Testing

4.3K views

Accuracy and Errors in Hypothesis Testing

2.6: Accuracy and Errors in Hypothesis Testing

409 views

Statistical Methods to Analyze Parametric Data: ANOVA

2.7: Statistical Methods to Analyze Parametric Data: ANOVA

956 views

Statistical Methods to Analyze Parametric Data: Student t-Test and Goodness-of-Fit Test

2.8: Statistical Methods to Analyze Parametric Data: Student t-Test and Goodness-of-Fit Test

3.8K views

Statistical Inference Techniques in Hypothesis Testing: Parametric Versus Nonparametric Data

2.9: Statistical Inference Techniques in Hypothesis Testing: Parametric Versus Nonparametric Data

281 views

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

2.10: Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

218 views

Chapter 3

Pharmacokinetics: Drug Absorption

29 Videos · 38 Minutes

Drug Administration and Therapy Phases: Overview

3.1: Drug Administration and Therapy Phases: Overview

932 views

Drug Absorption: Overview

3.2: Drug Absorption: Overview

1.2K views

Drug Delivery: Overview

3.3: Drug Delivery: Overview

537 views

Drug Delivery: Enteral Route

3.4: Drug Delivery: Enteral Route

1K views

Drug Delivery: Parenteral Route

3.5: Drug Delivery: Parenteral Route

1.1K views

Drug Delivery: Miscellaneous Routes

3.6: Drug Delivery: Miscellaneous Routes

588 views

Cellular Membranes and Drug Transport

3.7: Cellular Membranes and Drug Transport

1.1K views

Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport

3.8: Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport

1.1K views

Passive Diffusion: Overview and Kinetics

3.9: Passive Diffusion: Overview and Kinetics

1K views

Pore Transport and Ion-Pair Transport

3.10: Pore Transport and Ion-Pair Transport

850 views

Carrier-Mediated Transport

3.11: Carrier-Mediated Transport

722 views

Facilitated Diffusion

3.12: Facilitated Diffusion

843 views

Active Transport

3.13: Active Transport

1.4K views

Vesicular Trasport: Endocytosis, Transcytosis and Exocytosis

3.14: Vesicular Trasport: Endocytosis, Transcytosis and Exocytosis

2.1K views

Factors Influencing Drug Absorption: Anatomical Parameters

3.15: Factors Influencing Drug Absorption: Anatomical Parameters

389 views

Factors Influencing Drug Absorption: Disease States and Pharmacology

3.16: Factors Influencing Drug Absorption: Disease States and Pharmacology

1.1K views

Factors Influencing Drug Absorption: Physicochemical Parameters

3.17: Factors Influencing Drug Absorption: Physicochemical Parameters

633 views

Factors Influencing Drug Absorption: Pharmaceutical Parameters

3.18: Factors Influencing Drug Absorption: Pharmaceutical Parameters

249 views

Factors Influencing Drug Absorption: Drug Dissolution

3.19: Factors Influencing Drug Absorption: Drug Dissolution

865 views

Factors Influencing Drug Absorption: Presystemic Elimination

3.20: Factors Influencing Drug Absorption: Presystemic Elimination

564 views

Theories of Dissolution: Diffusion Layer Model

3.21: Theories of Dissolution: Diffusion Layer Model

1.2K views

Theories of Dissolution: The Danckwerts’ Model and Interfacial Barrier Model

3.22: Theories of Dissolution: The Danckwerts’ Model and Interfacial Barrier Model

549 views

Factors Affecting Dissolution: Particle Size and Effective Surface Area

3.23: Factors Affecting Dissolution: Particle Size and Effective Surface Area

1.2K views

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

3.24: Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

479 views

Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH

3.25: Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH

2.4K views

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

3.26: Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

325 views

Methods for Studying Drug Absorption: In vitro

3.27: Methods for Studying Drug Absorption: In vitro

430 views

Methods for Studying Drug Absorption: In situ

3.28: Methods for Studying Drug Absorption: In situ

448 views

Non-Oral Extravascular Drug Absorption Routes

3.29: Non-Oral Extravascular Drug Absorption Routes

369 views

Chapter 4

Pharmacokinetics: Drug Distribution and Protein Binding

14 Videos · 19 Minutes

Drug Distribution: Overview

4.1: Drug Distribution: Overview

457 views

Factors Affecting Drug Distribution: Tissue Permeability

4.2: Factors Affecting Drug Distribution: Tissue Permeability

382 views

Factors Affecting Drug Distribution: Physiological Barriers

4.3: Factors Affecting Drug Distribution: Physiological Barriers

475 views

Factors Affecting Drug Distribution: Organ Perfusion Rate

4.4: Factors Affecting Drug Distribution: Organ Perfusion Rate

393 views

Factors Affecting Drug Distribution: Miscellaneous Factors

4.5: Factors Affecting Drug Distribution: Miscellaneous Factors

691 views

Volume of Distribution

4.6: Volume of Distribution

724 views

Protein-Drug Binding: Mechanism and Kinetics

4.7: Protein-Drug Binding: Mechanism and Kinetics

1.3K views

Drug Binding to Blood Components

4.8: Drug Binding to Blood Components

325 views

Tissue-Drug Binding: Localization of Drugs and its Significance

4.9: Tissue-Drug Binding: Localization of Drugs and its Significance

244 views

Protein-Drug Binding: Determination Methods

4.10: Protein-Drug Binding: Determination Methods

391 views

Factors Affecting Protein-Drug Binding: Drug-Related Factors

4.11: Factors Affecting Protein-Drug Binding: Drug-Related Factors

299 views

Factors Affecting Protein-Drug Binding: Protein-Related Factors

4.12: Factors Affecting Protein-Drug Binding: Protein-Related Factors

353 views

Factors Affecting Protein-Drug Binding: Drug Interactions

4.13: Factors Affecting Protein-Drug Binding: Drug Interactions

378 views

Factors Affecting Protein-Drug Binding: Patient-Related Factors

4.14: Factors Affecting Protein-Drug Binding: Patient-Related Factors

167 views

Chapter 5

Pharmacokinetics: Drug Biotransformation

15 Videos · 20 Minutes

Drug Biotransformation: Overview

5.1: Drug Biotransformation: Overview

2K views

Phase I Oxidative Reactions: Overview

5.2: Phase I Oxidative Reactions: Overview

477 views

Phase I Reactions: Oxidation of Aliphatic and Aromatic Carbon-Containing Systems

5.3: Phase I Reactions: Oxidation of Aliphatic and Aromatic Carbon-Containing Systems

441 views

Phase I Reactions: Oxidation of Carbon-Heteroatom and Miscellaneous Systems

5.4: Phase I Reactions: Oxidation of Carbon-Heteroatom and Miscellaneous Systems

236 views

Phase I Reactions: Reductive Reactions

5.5: Phase I Reactions: Reductive Reactions

356 views

Phase I Reactions: Hydrolytic Reactions

5.6: Phase I Reactions: Hydrolytic Reactions

357 views

Phase II Conjugation Reactions: Overview

5.7: Phase II Conjugation Reactions: Overview

498 views

Phase II Reactions: Glucuronidation

5.8: Phase II Reactions: Glucuronidation

1.2K views

Phase II Reactions: Sulfation and Conjugation with α-Amino Acids

5.9: Phase II Reactions: Sulfation and Conjugation with α-Amino Acids

614 views

Phase II Reactions: Glutathione Conjugation and Mercapturic Acid Formation

5.10: Phase II Reactions: Glutathione Conjugation and Mercapturic Acid Formation

524 views

Phase II Reactions: Acetylation Reactions

5.11: Phase II Reactions: Acetylation Reactions

488 views

Phase II Reactions: Methylation Reactions

5.12: Phase II Reactions: Methylation Reactions

472 views

Phase II Reactions: Miscellaneous Conjugation Reactions

5.13: Phase II Reactions: Miscellaneous Conjugation Reactions

191 views

Factors Affecting Drug Biotransformation: Physicochemical and Chemical Properties of Drugs

5.14: Factors Affecting Drug Biotransformation: Physicochemical and Chemical Properties of Drugs

546 views

Factors Affecting Drug Biotransformation: Biological

5.15: Factors Affecting Drug Biotransformation: Biological

356 views

Chapter 6

Pharmacokinetics: Drug Excretion and Clearance

25 Videos · 30 Minutes

Drug Elimination: Overview

6.1: Drug Elimination: Overview

2.2K views

Elimination Kinetics: First-Order and Zero-Order

6.2: Elimination Kinetics: First-Order and Zero-Order

1.9K views

Renal Drug Excretion: Overview

6.3: Renal Drug Excretion: Overview

404 views

Renal Drug Excretion: Glomerular Filtration

6.4: Renal Drug Excretion: Glomerular Filtration

761 views

Renal Drug Excretion: Tubular Reabsorption

6.5: Renal Drug Excretion: Tubular Reabsorption

461 views

Renal Drug Excretion: Tubular Secretion

6.6: Renal Drug Excretion: Tubular Secretion

488 views

Renal Drug Excretion: Effect of Urine pH, Flow Rate, and Drug p<em>K</em>a

6.7: Renal Drug Excretion: Effect of Urine pH, Flow Rate, and Drug pKa

381 views

Hepatic Drug Excretion: Enterohepatic Cycling

6.8: Hepatic Drug Excretion: Enterohepatic Cycling

2.1K views

Hepatic Drug Excretion: Influencing Factors

6.9: Hepatic Drug Excretion: Influencing Factors

308 views

Drug Excretion: Pulmonary and Glandular Routes

6.10: Drug Excretion: Pulmonary and Glandular Routes

460 views

Drug Excretion: Miscellaneous Routes

6.11: Drug Excretion: Miscellaneous Routes

179 views

Drug Clearance: Overview

6.12: Drug Clearance: Overview

237 views

Clearance Models: Physiological Models

6.13: Clearance Models: Physiological Models

162 views

Clearance Models: Compartment Models

6.14: Clearance Models: Compartment Models

173 views

Clearance Models: Noncompartmental Models

6.15: Clearance Models: Noncompartmental Models

129 views

Renal Drug Clearance: Overview

6.16: Renal Drug Clearance: Overview

446 views

Renal Drug Clearance: Comparison Between Renal Excretion Methods

6.17: Renal Drug Clearance: Comparison Between Renal Excretion Methods

398 views

Factors Affecting Renal Clearance: Drug’s Physicochemical Properties and Plasma Levels

6.18: Factors Affecting Renal Clearance: Drug’s Physicochemical Properties and Plasma Levels

396 views

Factors Affecting Renal Clearance: Drug Distribution and Drug Interactions

6.19: Factors Affecting Renal Clearance: Drug Distribution and Drug Interactions

305 views

Factors Affecting Renal Clearance: Renal Impairment

6.20: Factors Affecting Renal Clearance: Renal Impairment

236 views

Renal Failure: Dose Adjustments

6.21: Renal Failure: Dose Adjustments

218 views

Determination of Renal Drug Clearance: Graphical and Midpoint Methods

6.22: Determination of Renal Drug Clearance: Graphical and Midpoint Methods

249 views

Hepatic Drug Clearance: Restrictive and Nonrestrictive Clearance

6.23: Hepatic Drug Clearance: Restrictive and Nonrestrictive Clearance

301 views

Hepatic Drug Clearance: Effect of Protein Binding

6.24: Hepatic Drug Clearance: Effect of Protein Binding

357 views

Hepatic Drug Clearance: Role of Transporters

6.25: Hepatic Drug Clearance: Role of Transporters

154 views

Chapter 7

Pharmacokinetic Models

30 Videos · 35 Minutes

Analysis Methods of Pharmacokinetic Data: Model and Model-Independent Approaches

7.1: Analysis Methods of Pharmacokinetic Data: Model and Model-Independent Approaches

294 views

Model Approaches for Pharmacokinetic Data: Compartment Models

7.2: Model Approaches for Pharmacokinetic Data: Compartment Models

321 views

One-Compartment Open Model for IV Bolus Administration: General Considerations

7.3: One-Compartment Open Model for IV Bolus Administration: General Considerations

443 views

One-Compartment Open Model for IV Bolus Administration: Estimation of Elimination Rate Constant, Half-Life and Volume of Distribution

7.4: One-Compartment Open Model for IV Bolus Administration: Estimation of Elimination Rate Constant, Half-Life and Volume of Distribution

600 views

One-Compartment Open Model for IV Bolus Administration: Estimation of Clearance

7.5: One-Compartment Open Model for IV Bolus Administration: Estimation of Clearance

181 views

One-Compartment Model: IV Infusion

7.6: One-Compartment Model: IV Infusion

341 views

One-Compartment Open Model for Extravascular Administration: Zero-Order Absorption Model

7.7: One-Compartment Open Model for Extravascular Administration: Zero-Order Absorption Model

235 views

One-Compartment Open Model for Extravascular Administration: First-Order Absorption Model

7.8: One-Compartment Open Model for Extravascular Administration: First-Order Absorption Model

355 views

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for <em>k</em><sub>a</sub> Estimation

7.9: One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for k_a Estimation

861 views

One-Compartment Open Model: Urinary Excretion Data and Determination of <em>k</em>

7.10: One-Compartment Open Model: Urinary Excretion Data and Determination of k

397 views

Multicompartment Models: Overview

7.11: Multicompartment Models: Overview

329 views

Two-Compartment Open Model: Overview

7.12: Two-Compartment Open Model: Overview

317 views

Two-Compartment Open Model: IV Bolus Administration

7.13: Two-Compartment Open Model: IV Bolus Administration

830 views

Two-Compartment Open Model: IV Infusion

7.14: Two-Compartment Open Model: IV Infusion

392 views

Two-Compartment Open Model: Extravascular Administration

7.15: Two-Compartment Open Model: Extravascular Administration

460 views

Three-Compartment Open Model

7.16: Three-Compartment Open Model

595 views

Mechanistic Models: Overview of Compartment Models

7.17: Mechanistic Models: Overview of Compartment Models

220 views

Mechanistic Models: Compartment Models in Individual and Population Analysis

7.18: Mechanistic Models: Compartment Models in Individual and Population Analysis

124 views

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

7.19: Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

155 views

Model Approaches for Pharmacokinetic Data: Physiological Models

7.20: Model Approaches for Pharmacokinetic Data: Physiological Models

151 views

Physiological Pharmacokinetic Models: Assumption with Protein Binding

7.21: Physiological Pharmacokinetic Models: Assumption with Protein Binding

124 views

Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models

7.22: Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models

188 views

Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance

7.23: Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance

128 views

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

7.24: Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

154 views

Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis

7.25: Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis

165 views

Noncompartmental Analysis: Statistical Moment Theory

7.26: Noncompartmental Analysis: Statistical Moment Theory

236 views

Noncompartmental Analysis: Mean Residence Time

7.27: Noncompartmental Analysis: Mean Residence Time

358 views

Noncompartmental Analysis: Mean Transit, Absorption and Dissolution Time

7.28: Noncompartmental Analysis: Mean Transit, Absorption and Dissolution Time

197 views

Noncompartmental Analysis: Miscellaneous Pharmacokinetic Parameters

7.29: Noncompartmental Analysis: Miscellaneous Pharmacokinetic Parameters

271 views

Pharmacokinetic Models: Comparison and Selection Criterion

7.30: Pharmacokinetic Models: Comparison and Selection Criterion

192 views

Chapter 8

Nonlinear Pharmacokinetics

12 Videos · 15 Minutes

Nonlinear Pharmacokinetics: Overview

8.1: Nonlinear Pharmacokinetics: Overview

736 views

Nonlinear Pharmacokinetics: Causes of Nonlinearity

8.2: Nonlinear Pharmacokinetics: Causes of Nonlinearity

451 views

Nonlinear Pharmacokinetics: Michaelis-Menten Equation

8.3: Nonlinear Pharmacokinetics: Michaelis-Menten Equation

623 views

Determination of Michaelis Constant and Maximum Elimination Rate

8.4: Determination of Michaelis Constant and Maximum Elimination Rate

225 views

Nonlinear Pharmacokinetics: Drug Elimination for IV Bolus Injection

8.5: Nonlinear Pharmacokinetics: Drug Elimination for IV Bolus Injection

200 views

Drug Distribution as One-Compartment Model and Elimination by Nonlinear Pharmacokinetics: Overview

8.6: Drug Distribution as One-Compartment Model and Elimination by Nonlinear Pharmacokinetics: Overview

172 views

Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model

8.7: Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model

166 views

Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance

8.8: Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance

389 views

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

8.9: Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

182 views

Chronopharmacokinetics: Time-Dependent Pharmacokinetics

8.10: Chronopharmacokinetics: Time-Dependent Pharmacokinetics

263 views

Nonlinear Pharmacokinetics: Bioavailability and Protein-Drug Binding

8.11: Nonlinear Pharmacokinetics: Bioavailability and Protein-Drug Binding

397 views

Nonlinear Pharmacokinetics: Role of Transporters

8.12: Nonlinear Pharmacokinetics: Role of Transporters

137 views

Chapter 9

Bioavailability and Bioequivalence

17 Videos · 22 Minutes

Bioavailability: Overview

9.1: Bioavailability: Overview

109 views

Bioavailability: Influencing Factors

9.2: Bioavailability: Influencing Factors

140 views

Bioavailability Study Design: Absolute Versus Relative Bioavailability

9.3: Bioavailability Study Design: Absolute Versus Relative Bioavailability

67 views

Bioavailability Study Design: Single Versus Multiple Dose Studies

9.4: Bioavailability Study Design: Single Versus Multiple Dose Studies

55 views

Bioavailability Study Design: Healthy Subjects Versus Patients

9.5: Bioavailability Study Design: Healthy Subjects Versus Patients

38 views

Measurement of Bioavailability: Pharmacokinetic Methods

9.6: Measurement of Bioavailability: Pharmacokinetic Methods

74 views

Measurement of Bioavailability: Pharmacodynamic Methods

9.7: Measurement of Bioavailability: Pharmacodynamic Methods

46 views

Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems

9.8: Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems

37 views

Bioavailability Enhancement: Drug Solubility Enhancement

9.9: Bioavailability Enhancement: Drug Solubility Enhancement

41 views

Bioavailability Enhancement: Drug Permeability Enhancement

9.10: Bioavailability Enhancement: Drug Permeability Enhancement

48 views

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

9.11: Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

40 views

Equivalence: <i>In Vitro</i> and <i>In Vivo</i> Bioequivalence

9.12: Equivalence: In Vitro and In Vivo Bioequivalence

54 views

Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs

9.13: Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs

50 views

Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs

9.14: Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs

50 views

Bioequivalence studies: Biowaivers

9.15: Bioequivalence studies: Biowaivers

52 views

Bioequivalence Data: Statistical Interpretation

9.16: Bioequivalence Data: Statistical Interpretation

45 views

Drug Products: Biologics, Biosimilars and Interchangeables

9.17: Drug Products: Biologics, Biosimilars and Interchangeables

66 views

Chapter 10

Biopharmaceutic Considerations in Drug Product Design and In Vitro Performance

9 Videos · 11 Minutes

Biopharmaceutical Factors Influencing Drug Product Design: Overview

10.1: Biopharmaceutical Factors Influencing Drug Product Design: Overview

64 views

<i>In Vitro</i> Drug Release Testing: Overview, Development and Validation

10.2: In Vitro Drug Release Testing: Overview, Development and Validation

62 views

<i>In Vitro</i> Drug Dissolution: Compendial Testing Models I

10.3: In Vitro Drug Dissolution: Compendial Testing Models I

52 views

<i>In Vitro</i> Drug Dissolution: Compendial Testing Models II

10.4: In Vitro Drug Dissolution: Compendial Testing Models II

44 views

<i>In Vitro</i> Drug Dissolution: Alternative Methods

10.5: In Vitro Drug Dissolution: Alternative Methods

45 views

10.6: Drug Dissolution: Requirements and Profile Comparison

81 views

Drug Product Performance: <i>In Vitro–In Vivo</i> Correlation

10.7: Drug Product Performance: In Vitro–In Vivo Correlation

61 views

Clinically Relevant Drug Product Specifications: Methods of Establishment

10.8: Clinically Relevant Drug Product Specifications: Methods of Establishment

55 views

Drug Product Stability

10.9: Drug Product Stability

47 views

Chapter 11

Biopharmaceutical Aspects of Active Pharmaceutical Ingredients

7 Videos · 9 Minutes

Pharmaceutical Equivalents

11.1: Pharmaceutical Equivalents

52 views

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

11.2: Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

47 views

Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence

11.3: Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence

48 views

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

11.4: Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

46 views

Bioequivalence of Drugs: Drugs with Multiple Indications

11.5: Bioequivalence of Drugs: Drugs with Multiple Indications

47 views

Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules

11.6: Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules

40 views

FDA Approved Drugs: Changes to Approved Drugs

11.7: FDA Approved Drugs: Changes to Approved Drugs

40 views

Chapter 12

Clinical Pharmacokinetics I

17 Videos · 23 Minutes

Dosage Regimens: Designs and Approaches

12.1: Dosage Regimens: Designs and Approaches

97 views

Dosage Regimens: Partial Pharmacokinetic Parameters

12.2: Dosage Regimens: Partial Pharmacokinetic Parameters

40 views

Dosage Regimen: Multiple Oral Dosage

12.3: Dosage Regimen: Multiple Oral Dosage

57 views

Dosage Regimen: Individualization

12.4: Dosage Regimen: Individualization

44 views

Dosage Regimen Designs: Nomograms and Tabulations

12.5: Dosage Regimen Designs: Nomograms and Tabulations

49 views

Dose Size and Dosing Frequency: Determination Methods

12.6: Dose Size and Dosing Frequency: Determination Methods

47 views

Dosage Interval and Administration Route: Determination Methods

12.7: Dosage Interval and Administration Route: Determination Methods

58 views

Drug Accumulation During Multiple Dosing: Repetitive IV Injections

12.8: Drug Accumulation During Multiple Dosing: Repetitive IV Injections

73 views

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

12.9: Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

65 views

Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations

12.10: Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations

101 views

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

12.11: Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

49 views

Estimation of <i>k</i> and <i>V</i><sub>D</sub> of Aminoglycosides

12.12: Estimation of k and V_D of Aminoglycosides

50 views

Therapeutic Drug Monitoring: Overview and Classification

12.13: Therapeutic Drug Monitoring: Overview and Classification

77 views

Therapeutic Drug Monitoring: Affecting Factors

12.14: Therapeutic Drug Monitoring: Affecting Factors

51 views

Therapeutic Drug Monitoring: Drug Analysis Methods

12.15: Therapeutic Drug Monitoring: Drug Analysis Methods

37 views

Pharmacokinetics: Drug–Drug Interactions

12.16: Pharmacokinetics: Drug–Drug Interactions

65 views

Pharmacokinetics: Drug–Food and Drug–Viral Interactions

12.17: Pharmacokinetics: Drug–Food and Drug–Viral Interactions

48 views

Chapter 13

Clinical Pharmacokinetics II

24 Videos · 32 Minutes

Drug Dosing: Infants and Children

13.1: Drug Dosing: Infants and Children

71 views

Drug Dosing: Obese Patients

13.2: Drug Dosing: Obese Patients

43 views

Drug Dosing: Geriatric Patients

13.3: Drug Dosing: Geriatric Patients

66 views

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

13.4: Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

49 views

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

13.5: Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

42 views

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

13.6: Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

50 views

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

13.7: Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

107 views

Pharmacodynamics in Geriatric Patients: Effects of Age

13.8: Pharmacodynamics in Geriatric Patients: Effects of Age

59 views

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

13.9: Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

63 views

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

13.10: Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

43 views

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

13.11: Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

53 views

Pharmacokinetics in Pediatric Patients: Drug Distribution

13.12: Pharmacokinetics in Pediatric Patients: Drug Distribution

84 views

Pharmacokinetics in Pediatric Patients: Drug Metabolism

13.13: Pharmacokinetics in Pediatric Patients: Drug Metabolism

53 views

Pharmacokinetics in Pediatric Patients: Drug Excretion

13.14: Pharmacokinetics in Pediatric Patients: Drug Excretion

62 views

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

13.15: Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

56 views

Effect of Hepatic Disease on Pharmacokinetics: Active Drug, Metabolite and Fraction of Metabolized Drug

13.16: Effect of Hepatic Disease on Pharmacokinetics: Active Drug, Metabolite and Fraction of Metabolized Drug

55 views

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

13.17: Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

47 views

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

13.18: Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

57 views

Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance

13.19: Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance

46 views

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

13.20: Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

46 views

Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant

13.21: Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant

43 views

Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis

13.22: Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis

75 views

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

13.23: Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

49 views

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

13.24: Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

34 views

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