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The three major somatic sensory pathways are the posterior column-medial lemniscus, spinothalamic, and spinocerebellar pathways. The posterior column-medial lemniscus transmits touch and proprioceptive information to the cerebral cortex. The spinothalamic pathway carries pain, temperature, and crude touch signals. The spinocerebellar pathway sends proprioceptive information to the cerebellum for coordination and balance.

First-order neurons carry sensory impulses into the spinal cord's posterior columns, which contain the gracile tract for lower body sensations and cuneate tract for upper body sensations. These axons synapse with second-order neurons in the medulla's gracile or cuneate nucleus, which cross over and form the medial lemniscus tract. Third-order neurons in the thalamus then project to the primary somatosensory cortex.

The spinothalamic pathway transmits pain, temperature, itch, and tickle sensations from body parts to the cerebral cortex. It consists of the lateral spinothalamic tract, which carries pain and temperature information, and the anterior spinothalamic tract, which transmits crude touch. First-order neurons synapse with second-order neurons in the spinal cord's posterior gray horn, which cross over and ascend as the spinothalamic tract.

The gracile fasciculus carries sensory impulses from the lower body, while the cuneate fasciculus carries impulses from the upper body. Both tracts are part of the posterior columns and transmit touch, pressure, vibration, and proprioceptive information. They synapse with second-order neurons in the medulla's respective nuclei before crossing over to form the medial lemniscus tract.

The spinocerebellar pathway transmits proprioceptive information from muscles, tendons, and joints directly to the cerebellum for coordination and balance. The dorsal and ventral spinocerebellar tracts carry impulses from the lower extremities, while the cuneocerebellar and rostral spinocerebellar tracts transmit similar information from the upper extremities. These sensory impulses regulate movements and maintain balance without conscious perception.

Second-order neurons cross over to the opposite side of the spinal cord or medulla to ensure that sensory information from one side of the body reaches the opposite hemisphere of the cerebral cortex. This decussation, or crossing over, allows for contralateral sensory representation in the brain. The spinocerebellar pathway is an exception, with neurons either not crossing or crossing twice to reach the same-side cerebellum.

All three major somatic sensory pathways involve three-order neurons that relay information through the thalamus or directly to the cerebellum. For the posterior column-medial lemniscus and spinothalamic pathways, third-order neurons in the thalamus project to the primary somatosensory cortex. The spinocerebellar pathway bypasses the thalamus, sending proprioceptive information directly to the cerebellum for unconscious coordination.