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The retina contains rods and cones, two distinct photoreceptor types. Rods contain one form of opsin and retinal, enabling noncolor vision in dim light due to their high light sensitivity. Cones exist in three types—red, green, and blue—each containing different opsins that selectively activate photopigments to provide color vision under brighter conditions.

When a photon strikes the retinal molecule in a photoreceptor, it triggers photoisomerization—a structural change converting 11-cis-retinal to all-trans-retinal. This transformation activates retinal and opsin proteins, which stimulate a G protein that alters the photoreceptor cell's membrane potential, decreasing neurotransmitter release and initiating the visual signal cascade.

Rods contain rhodopsin, which exhibits peak sensitivity at 498 nm wavelength and can be activated by a single photon. Cone opsins are less sensitive and require higher light intensity to stimulate. In dim lighting, cone opsins cannot activate, making vision entirely dependent on rods, which is why low-light vision appears monochromatic in shades of gray.

The three cone types respond optimally to wavelengths of 564 nm (red), 534 nm (green), and 420 nm (blue). When light enters the eye, each cone type activates differentially based on its wavelength sensitivity. The brain analyzes this differential activation pattern across all three cone types and interprets the combined signal as a specific color perception.

Bipolar cells convert the electrical signal detected by photoreceptors and pass it to ganglion cells. Ganglion cells form the optic nerve, which carries the visual signal through the optic chiasma to the primary visual cortex in the brain for visual perception and interpretation of the image.

Night blindness, or nyctalopia, results from photopigment depletion or irregular synthesis, impairing rod function in dim light. Color blindness, or achromatopsia, stems from congenital absence of cone pigments, preventing color discrimination. Both conditions involve defects in photoreceptor pigments that compromise specific visual capabilities.

Bleaching occurs when photopigments undergo structural changes and the retinal molecule reverts to its original 11-cis-retinal form through enzymatic processes. When substantial photopigments bleach, the retina transmits data as if contrasting visual inputs are received, producing afterimages typically seen as negative-type images following intense light exposure.