Question 1

What is the blood-brain barrier and why does it restrict certain drugs?

Accepted Answer

The blood-brain barrier is a specialized, semi-permeable membrane separating circulating blood from the brain's extracellular fluid. It consists of tightly packed endothelial cells, astrocytic end-feet, and a basement membrane, creating a highly selective interface. The BBB restricts water-soluble drugs like dopamine while allowing small lipophilic molecules and essential nutrients to pass through.

Question 2

How does the capillary endothelial barrier affect drug passage?

Accepted Answer

The capillary endothelial barrier permits only smaller molecules below 600 Daltons to pass through. It also restricts drugs like heparin that are bound to blood components, limiting their movement within the bloodstream. This barrier acts as a size-selective gatekeeper for drug distribution throughout the body.

Question 3

Why is levodopa used to treat Parkinson's disease instead of dopamine?

Accepted Answer

Dopamine is water-soluble and cannot cross the blood-brain barrier, making it ineffective for treating Parkinson's disease. Levodopa, however, can cross the BBB and enter the central nervous system, where it is converted into dopamine. This allows the drug to reach brain tissue and mitigate Parkinson's symptoms.

Question 4

What determines whether drugs can cross the blood-placental barrier?

Accepted Answer

The blood-placental barrier allows moderate to highly lipid-soluble drugs with a molecular weight below 1000 Daltons to cross via simple diffusion. Substances like barbiturates, steroids, and anticonvulsants can penetrate this barrier, influencing fetal exposure. Lipophilicity and molecular weight are the primary determinants of placental drug passage.

Question 5

How does the blood-testis barrier protect developing sperm cells?

Accepted Answer

The blood-testis barrier is formed by tight junctions between Sertoli cells in the testes, restricting drug passage to spermatocytes. Efflux pumps further reinforce this barrier by preventing the entry of cytotoxic drugs like doxorubicin. This dual protection mechanism safeguards the delicate process of spermatogenesis from harmful substances.

Question 6

Why do drugs sometimes achieve higher concentrations in cerebrospinal fluid than in brain tissue?

Accepted Answer

The blood-cerebrospinal fluid barrier permits highly lipid-soluble drugs to enter the CSF. However, drugs face challenges maintaining high concentrations due to continuous removal by the CSF's bulk flow. Certain drugs like sulfamethoxazole can achieve higher CSF concentrations than cerebral concentrations due to differential clearance rates.

Question 7

What role do efflux pumps play in drug distribution across physiological barriers?

Accepted Answer

Efflux pumps actively transport drugs out of cells, preventing entry of certain substances across physiological barriers. These pumps restrict cytotoxic drugs like doxorubicin from entering protected tissues such as the testes and brain. Efflux pumps work alongside tight junctions and selective permeability to regulate drug distribution and protect vital organs.

약물 분포에 영향을 미치는 요인: 생리적 장벽