Vagina Cervix
Vagina Cervix - Related Videos
01:26
Vagina
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2025
The vaginal canal is a tubular structure averaging about 10 cm in length that acts as the entryway to the female reproductive system and the passageway for menstrual flow and childbirth. The interior walls of the vagina exhibit concentric folds called rugae and are topped by an area known as the fornix, which connects with the protruding cervical portion of the uterus. This canal is comprised of an external fibrous layer, a muscular middle layer, and an inner lining with mucosal rugae, which...
01:18
Uterus and Cervix
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2025
The uterus, commonly called the womb, is a vital reproductive organ in females designed to provide a nurturing environment for the implantation and growth of an embryo. It is shaped like a hollow pear and positioned between the urinary bladder and the rectum. The uterus's structure allows it to support and protect a developing fetus throughout pregnancy. The uterus is securely anchored within the pelvic cavity by paired broad ligaments on either side. It is further stabilized by three pairs of...
08:15
Modeling Healthy and Dysbiotic Vaginal Microenvironments in a Human Vagina-on-a-Chip
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Cited by 6 •
2024
This article describes a protocol for creating a microfluidic vagina-on-a-chip (Vagina Chip) culture device that enables the study of human host interactions with a living vaginal microbiome under microaerophilic conditions. This chip can be used as a tool to investigate vaginal diseases as well as to develop and test potential therapeutic countermeasures.
08:30
Tissue Processing and Isolation of Primary Fibroblasts from the Human Vagina
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Cited by 1 •
2024
This protocol demonstrates a reliable and effective technique to isolate primary fibroblasts from either premenopausal or postmenopausal human vaginal tissue. Existing protocols for vaginal fibroblast isolation do not consider the challenges of cell isolation from senescent tissue. Vaginal tissue was obtained from women after pelvic organ prolapse surgery.
13:01
Pelvic Exam III: Bimanual and Rectovaginal Exam
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2023
Source: Alexandra Duncan, GTA, Praxis Clinical, New Haven, CT Tiffany Cook, GTA, Praxis Clinical, New Haven, CT Jaideep S. Talwalkar, MD, Internal Medicine and Pediatrics, Yale School of Medicine, New Haven, CT A bimanual exam is a thorough check of a patient's cervix, uterus, and ovaries. It can tell an experienced provider a great deal, as it may lead to the discovery of abnormalities, such as cysts, fibroids, or malignancies. However, it's useful even in the absence of such findings, as it...
FAQs
These tissue layers provide complementary properties rather than a single barrier function. Specialized epithelium supports protection and lubrication, while connective tissue contributes structural support and elasticity. Smooth muscle supplies contractile behavior. Reproducing this layered organization in engineered systems can make models more representative of how the vagina and cervix function together.
Cervical mucus changes in composition and viscosity under different hormonal conditions. Those changes influence barrier protection, lubrication, and the movement of sperm through the cervix. For bioengineered models, mucus is therefore an important variable to represent when studying reproductive processes, because a fixed material may not reproduce condition-dependent transport or protection.
The vagina and cervix regulate communication between the uterus and the external environment through linked tissues and secretions. Modeling only one structure can omit interactions involving epithelial barriers, supporting tissues, smooth muscle, and cervical mucus. Integrated systems can better examine how changes at one site affect protection, transport, or tissue responses at the other.
Three-dimensional tissue models recreate aspects of the relevant tissue organization in a laboratory platform. Bioengineers can use them to represent epithelial, connective, and smooth muscle features while incorporating the roles of cervical mucus. These models support investigation of infection, reproductive health, drug delivery, and tissue repair in a controlled experimental setting.
Biomaterials provide the engineered setting in which tissue-related properties and responses can be studied. In vagina and cervix research, they can be incorporated into three-dimensional models or related platforms designed around barrier protection, lubrication, transport, or repair. Their use supports more targeted evaluation of how therapies interact with reproductive tissues.
Organ-on-chip systems are useful when researchers need a platform for studying tissue behavior and treatment responses in a controlled model. Applied to the vagina and cervix, they can support disease modeling, reproductive-health studies, drug-delivery research, and tissue-repair investigations. These systems may improve therapeutic evaluation without relying solely on animal studies.