Biomolecular Sensing
Biomolecular Sensing - Related Videos
07:26
Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
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Cited by 6 •
2013
This paper describes the formation of highly ordered peptide-based structures by the spontaneous process of self-assembly. The method utilizes commercially available peptides and common lab equipment. This technique can be applied to a large variety of peptides and may lead to the discovery of new peptide-based assemblies.
04:17
Approximate Number Sense Test
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2023
Source: Laboratory of Jonathan Flombaum—Johns Hopkins University A common carnival game is to ask people to guess the number of jellybeans packed into a jar. The chances that anyone will get the exact number right are low. But what about the chances that someone will guess 17 or 147,000? Probably even less than the chances of guessing the correct answer; 17 and 147,000 just seem irrational. Why? After all, if the beans cannot be taken out and counted one-at-a-time, how can someone tell that an...
09:17
3D Printing of Biomolecular Models for Research and Pedagogy
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Cited by 29 •
2017
Physical models of biomolecules can facilitate an understanding of their structure-function for the researcher, aid in communication between researchers, and serve as an educational tool in pedagogical endeavors. Here, we provide detailed guidance for the 3D printing of accurate models of biomolecules using fused filament fabrication desktop 3D printers.
05:15
The Rouge Test: Searching for a Sense of Self
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2023
Source: Laboratories of Nicholaus Noles and Judith Danovitch—University of Louisville Humans are different from other animals in many ways, but one of the abilities that sets humans apart is their advanced ability to understand other people and simulate their thoughts and feelings, even when the thoughts and feelings do not align with their own. In scientific terms, these abilities are referred to as theory of mind, and this understanding is necessary for activities like giving compliments,...
05:21
Surface Plasmon Resonance to Study Biomolecular Interactions Using a Sensor Chip
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2025
This video describes the surface plasmon resonance, or SPR, technique for studying the interaction between two molecules using a sensor chip. The change in resonance angle and the intensity of the reflected light are detected as a function of the association and dissociation of two molecules, and this provides information about the interactions between the two molecules.
FAQs
Performance depends on how the recognition element and transducer are integrated. Selective binding or reaction creates a molecular event, but that event must be converted into a stable, measurable signal. Engineering this interface helps preserve target specificity while making the output suitable for optical, electrical, mechanical, or chemical readout.
Selectivity and sensitivity are influenced by recognition behavior, sensor materials, sample handling, microfluidic design, and signal processing. Materials can influence molecular interactions, while microfluidics manages small sample volumes and transport. Signal processing helps extract meaningful changes from the transducer output, improving practical measurement quality.
No single transduction mode is universally preferable. Optical, electrical, mechanical, and chemical approaches convert recognition events into different measurable outputs, so engineering selection depends on the required form of information and operating context. Comparing these modes helps match sensor architecture to goals such as targeted analysis, portability, or continuous monitoring.
A practical workflow begins by presenting a biological sample to the recognition element, followed by observation of the binding or reaction event. The engineered system routes that event through a transducer and applies signal processing to produce interpretable information. Controlling sample volume and measurement conditions supports rapid, targeted analysis and improves consistency.
Microfluidic integration can reduce the amount of sample required and help control how material reaches the sensing region. Combined with suitable materials and signal processing, it supports portable platforms and may enable repeated or continuous measurements. These engineering choices are especially relevant when rapid analysis or ongoing monitoring is needed.
Applications span medical diagnostics, environmental monitoring, food safety, and biotechnology. In each case, the engineering challenge is to obtain targeted molecular information rapidly, often from small sample volumes. Design advances in materials, microfluidics, and signal processing can improve portability, sensitivity, selectivity, and the capability for real-time monitoring.