Optical Beam Deflection
Optical Beam Deflection - Related Videos
10:02
Submillisecond Conformational Changes in Proteins Resolved by Photothermal Beam Deflection
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Cited by 1 •
2014
Here we report an application of the photothermal beam deflection technique in combination with a caged calcium compound, DM-nitrophen, to monitor microsecond and millisecond dynamics and energetics of structural changes associated with the calcium association to a neuronal calcium sensor, Downstream Regulatory Element Antagonist Modulator.
01:19
Deflection of a Beam
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2024
Accurately determining beam deflection and slope under various loading conditions in structural engineering is crucial for ensuring safety and structural integrity. Singularity functions offer a streamlined approach to analyzing beams, especially when multiple loading functions complicate the bending moment equation. Singularity functions, described in an earlier lesson, are powerful mathematical tools that represent discontinuities within a function commonly encountered in structural loading...
12:14
The Generation of Higher-order Laguerre-Gauss Optical Beams for High-precision Interferometry
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Cited by 7 •
2013
Large laser-interferometers are being constructed to create a new type of astronomy based on gravitational waves. Their sensitivities, as for many other high-precision experiments, are approaching fundamental noise limits such as the atomic vibration of their components. We are pioneering technologies to overcome these limits using novel laser beam shapes.
01:13
Maximum Deflection
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2024
When analyzing beams under unsymmetrical loads, such as a train moving on a bridge, it is crucial to accurately determine the points of maximum stress and deflection. The process involves identifying the maximum deflection of the beam, which may not always occur at its midpoint due to the uneven distribution of the load. The maximum deflection occurs at a specific point, known as point O, where the tangent to the deflection curve is horizontal. To find point O, the slope of the tangent at any...
11:27
Magnetically-Assisted Remote Controlled Microcatheter Tip Deflection under Magnetic Resonance Imaging
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Cited by 10 •
2013
Current applied to an endovascular microcatheter with microcoil tip made by laser lathe lithography can achieve controllable deflections under magnetic resonance (MR) guidance, which may improve speed and efficacy of navigation of vasculature during various endovascular procedures.
FAQs
Immune recognition changes the surface stress of a functionalized microcantilever. When antigens, antibodies, or pathogens bind at that surface, the cantilever bends slightly. The resulting mechanical deformation changes the reflected beam angle, converting a molecular interaction into a detectable optical displacement. This connection between binding, surface stress, and cantilever motion enables real-time monitoring of recognition events.
The functionalized microcantilever provides the surface where immune or pathogen-related binding occurs. A laser reflects from that structure, and its direction changes when the cantilever bends. The position-sensitive detector records the beam displacement, supplying the measurement used to identify the mechanical response. Together, these components connect molecular binding at the surface with an optical readout.
The label-free format allows immune recognition and pathogen interactions to be monitored without relying on an added detection label. This supports direct observation of binding-related mechanical changes at the functionalized surface and preserves real-time measurement of the interaction. In immunology and infection research, that capability can help examine molecular recognition involving antigens, antibodies, pathogens, cytokines, and other biomarkers.
A typical workflow begins with a functionalized microcantilever and alignment of a laser so that light reflects from its surface toward a position-sensitive detector. When the selected biological targets bind at the cantilever, surface stress changes and the structure bends. The detector then tracks the reflected beam's angular displacement, providing the measurement signal for the interaction.
The approach can be applied to immune-recognition and infection-related targets described in the source material, including antigens, antibodies, pathogens, cytokines, and other biomarkers. By following binding-associated cantilever responses in real time, researchers can investigate molecular interactions during infection and support the development of diagnostic assays for infectious agents and immune-related signals.
Optical Beam Deflection can reveal whether molecular interactions at a functionalized microcantilever produce detectable surface-stress changes. Its high sensitivity and real-time capability make it useful for studying immune recognition, pathogen interactions, and biomarker detection. These measurements can contribute to immunological research, diagnostic assay development, and broader investigations of molecular events associated with infection.