Pulmonary Perfusion
Pulmonary Perfusion - Related Videos
05:30
Ex vivo Lung Perfusion: A Technique for Pulmonary Research in a Rabbit Model
0 Views •
2025
This video shows an ex vivo technique for isolated lung perfusion. It is a tool for pulmonary research that will aid studies of various physiological and pathological mechanisms involved in lung transplantation procedures.
12:29
Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling
0 Views •
Cited by 18 •
2011
A MR imaging method to study the distribution of pulmonary blood flow under a variety of physiological conditions, in this case exposure to three different inspired oxygen concentrations: hypoxia, normoxia, and hyperoxia, is described. This technique utilizes human pulmonary physiology research techniques in an MR scanning environment.
03:44
Langendorff Retrograde Heart Perfusion: An Ex Vivo Technique to Perfuse Isolated Mouse Heart
0 Views •
2025
In this video, we perform Langendorff retrograde perfusion of an isolated mouse heart. During the procedure, the cardiac activity of the heart is maintained by perfusing it retrogradely with a perfusion solution via the coronary arteries using a cannula inserted into the ascending aorta. The model is used to study the cardiac pathophysiology of the heart.
04:44
Antegrade Perfusion Model: An Ex Vivo Technique to Perfuse Isolated Mouse Heart
0 Views •
2025
This video describes an antegrade perfusion technique of an isolated mouse heart during which a perfusate is injected through the left ventricle, and eventually, it perfuses the entire myocardium. This method can be used to isolate cardiomyocytes from murine models and generate decellularized hearts for further downstream applications.
06:10
Determination of Cardiac Output in a Porcine Model for Ex Vivo Pulmonary Perfusion
0 Views •
2024
This protocol describes the surgical technique used for the placement of a thermodilution catheter through the jugular vein in pigs to estimate cardiac output and ensure adequate lung perfusion during ex vivo lung perfusion (EVLP).
FAQs
Gravity and regional pressure differences make pulmonary blood flow unevenly distributed, with perfusion generally greater toward the lung bases than the apices. This creates regional variation in how much blood reaches alveolar capillaries. The pattern matters because gas exchange depends not only on total pulmonary blood flow, but also on where that flow is distributed within the lungs.
Efficient oxygen uptake requires alignment between ventilation, which brings air to the alveoli, and perfusion, which brings blood to their capillaries. When these processes are mismatched, some blood may receive inadequate oxygenation, impairing arterial oxygen levels. Pulmonary perfusion therefore must be considered together with ventilation when evaluating respiratory function and gas-exchange problems.
The right ventricle supplies the pressure needed to move blood into the pulmonary circulation, where oxygen uptake occurs before blood returns through the pulmonary veins. Consequently, changes affecting right-heart function can influence the amount of blood available for gas exchange and the oxygen delivered to the body. This links pulmonary perfusion to overall cardiopulmonary performance.
A disruption in pulmonary perfusion can reduce the amount or distribution of blood reaching alveolar capillaries, disturbing the relationship between blood flow and ventilation. The resulting mismatch may impair arterial oxygenation. This mechanism provides an important physiological context for conditions such as pulmonary embolism and other disorders that interfere with normal cardiopulmonary function.
Pulmonary perfusion is relevant because a pulmonary embolism can interfere with blood flow through the pulmonary circulation and thereby alter access to ventilated alveoli. Clinicians use the resulting physiological concern, especially possible ventilation-perfusion mismatch and impaired oxygenation, as part of the broader assessment of disorders affecting pulmonary blood flow and gas exchange.
Pulmonary perfusion helps frame how disease affects the interaction between pulmonary blood flow, the right heart, alveolar gas exchange, and systemic oxygen delivery. In pulmonary hypertension, altered conditions within the pulmonary circulation may challenge this relationship; in respiratory disease, impaired matching with ventilation may reduce oxygenation. These links support cardiopulmonary diagnosis and management.