Pulmonary Hilum Clamping
Pulmonary Hilum Clamping - Related Videos
08:17
Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery
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Cited by 8 •
2017
The following protocol describes the methodology for the acquisition and analysis of echocardiographic images used to obtain the Left Atrial Volume (LAV), Aorta (Ao) diameter, and Pulmonary Artery (PA) diameter in mice. This technique is a non-invasive, non-terminal procedure that allows assessment of the cardiopulmonary function.
13:32
Videomorphometric Analysis of Hypoxic Pulmonary Vasoconstriction of Intra-pulmonary Arteries Using Murine Precision Cut Lung Slices
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Cited by 29 •
2014
Hypoxic pulmonary vasoconstriction (HPV) is an important physiological phenomenon by which at alveolar hypoxia lung perfusion is matched to ventilation. The major vascular segment contributing to HPV is the intra-acinar artery. Here, we describe our protocol for the analysis of HPV of murine pulmonary vessels with diameters of 20-100 μm.
07:06
Selective Harvesting of Marginating-pulmonary Leukocytes
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Cited by 1 •
2016
Marginating-pulmonary leukocytes exhibit unique characteristics and distinct immunological functions compared to other leukocyte populations. Here we describe selective harvesting of this subpopulation of pulmonary leukocytes, by forced perfusion of the lungs in rats and mice. Marginating-pulmonary leukocytes seem critical in determining susceptibility to blood-borne and lung-related diseases.
06:45
Murine Left Pulmonary Hilar Clamp Model of Lung Ischemia Reperfusion Injury
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Cited by 4 •
2024
The protocol outlines a feasible, reliable, and reproducible method of left pulmonary hilar clamping that can be used to study lung ischemia-reperfusion injury in mouse models.
04:19
Pressure Fixation of Isolated Murine Pulmonary Valve: A Procedure to Isolate and Chemically Fix the Mouse Pulmonary Valve in Closed Conformation
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2025
In this video, we describe the procedure to isolate and chemically fix the mouse pulmonary value in closed conformation via perfusion pressurization.
FAQs
The pulmonary hilum carries the pulmonary artery and pulmonary veins, so controlling the region limits blood movement into and out of the lung at the same time. This makes the maneuver useful when hemorrhage must be contained quickly, particularly in thoracic trauma or complex lung resection where individual structures may be difficult to control immediately.
Because the main bronchus is included with the hilar structures, clamping interrupts airflow to the affected lung as well as its pulmonary blood flow. The resulting physiological changes can impair oxygenation, so clinicians must account for respiratory effects while the hilum is controlled and remain alert for deterioration during the maneuver.
Safe control depends on recognizing how the pulmonary artery, pulmonary veins, and main bronchus are arranged within the hilum and connected toward the mediastinum. Understanding these relationships helps the surgeon control the intended structures together, reduce unintended injury, and anticipate the circulatory and respiratory consequences of temporarily excluding the lung.
The principal concerns are hemodynamic instability and impaired oxygenation. Occluding the hilar structures changes pulmonary blood flow while also stopping airflow through the main bronchus, creating simultaneous circulatory and respiratory effects. These risks make physiological observation essential throughout control of the hilum and during management of the underlying thoracic problem.
The surgeon first identifies the hilar region and its major vascular and airway components, then applies temporary en bloc control to the structures connecting the lung with the mediastinum. The team evaluates the resulting control of bleeding and contamination while monitoring physiological effects. Once the surgical objective is addressed, control is managed according to the procedure’s requirements.
Pulmonary Hilum Clamping may be considered when rapid control of the lung is needed, including thoracic trauma, complex lung resection, and selected operations involving the lung or its hilar connection. Its value is greatest when controlling pulmonary blood flow, airflow, hemorrhage, or contamination is more urgent than addressing each hilar structure separately.
Controlling the main bronchus can prevent ongoing airflow through the affected lung, while vascular control limits movement of blood through the pulmonary circulation. Together, these effects can restrict the spread of blood or other material from the injured or operated lung into the surgical field, supporting operative control during selected thoracic procedures.
Assessment should focus on whether hemorrhage and operative contamination are controlled without unacceptable physiological deterioration. Clinicians should specifically watch for hemodynamic instability and impaired oxygenation, because the maneuver simultaneously affects pulmonary circulation and airway flow. This monitoring links the anatomical action to its clinical consequences and helps guide safe management during surgery.