Tumor Size Assessment
Tumor Size Assessment - Related Videos
10:44
Production of Large Numbers of Size-controlled Tumor Spheroids Using Microwell Plates
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Cited by 36 •
2013
We introduce a protocol for the generation of large numbers (thousands to hundreds of thousands) of uniform size- and composition-controlled tumor spheroids, using commercially available microwell plates.
02:08
Bioluminescence Imaging to Assess Tumor Growth in an Organotypic Mouse Brain Slice
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2025
Source: Ciraku, L., et. al. An Ex Vivo Brain Slice Model to Study and Target Breast Cancer Brain Metastatic Tumor Growth. J. Vis. Exp. (2021).This video demonstrates the imaging of luciferase-expressing tumor cells in an organotypic mouse brain slice. Luciferin is added to the medium, and the plate is placed inside the chamber of the in vivo imaging system. Parameters for image capture are adjusted, and the tumor's shape and size are defined. The bioluminescent signals emitted by the tumor...
02:18
Visualization and Size Assessment of Faustovirus Using Electron Microscopy
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2026
Source: Bou Khalil, J. Y., et al. A Rapid Strategy for the Isolation of New Faustoviruses from Environmental Samples Using Vermamoeba vermiformis. J. Vis. Exp. (2016).This video demonstrates imaging of faustovirus particles from an infected amoeba culture using transmission electron microscopy. It covers grid preparation, negative staining with ammonium molybdate to enhance contrast, and visualization of the virus under the microscope. The protocol concludes with measuring the size of the...
06:33
Construction of a Preclinical Multimodality Phantom Using Tissue-mimicking Materials for Quality Assurance in Tumor Size Measurement
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Cited by 1 •
2013
This paper describes in-house procedures of constructing a preclinical multimodality phantom made of tissue-mimicking (TM) materials for quality assurance (QA) of tumor size measurement in animal imaging modalities such as ultrasound (US), computed tomography (CT) and magnetic resonance imaging (MRI).
04:11
DCE-MRI of Orthotopic Pancreatic Tumor Xenografts: A Method to Assess Microvasculature in a Target Tumor Tissue
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2023
This video describes the technique of DCE-MRI for orthotropic pancreatic tumor xenografts in mice. DCE-MRI is a non-invasive method to analyze microvasculature in a target tissue, and useful to assess vascular response in a tumor following a novel therapy. This method will assist investigators to apply DCE-MRI for orthotopic gastrointestinal cancer mouse models.
FAQs
Reliable interpretation depends on comparing like with like. The same lesion should be assessed with standardized acquisition, measurement, and reporting practices, while imaging conditions are documented or considered during interpretation. This consistency helps distinguish genuine change in tumor burden from a small difference introduced by the assessment process itself.
A tumor’s shape affects how well a single dimensional measurement represents its overall size. For this reason, assessment may document dimensions or volume, depending on what the study provides. Accounting for shape makes comparisons more meaningful, particularly when serial observations show small changes that could otherwise be overinterpreted.
The baseline establishes the initial reference point against which later measurements are compared. Subsequent assessments can then be interpreted as changes from that starting condition rather than as isolated observations. In oncology, this reference supports evaluation of whether disease burden appears stable, reduced, or increased during follow-up.
Measurements may come from CT, MRI, or ultrasound, and they may also be obtained through direct examination or pathology. These sources can document lesion dimensions or volume in different clinical settings. The resulting measurements become most useful when their acquisition and reporting methods remain consistent enough to support comparison over time.
Clinicians compare standardized measurements from serial assessments to evaluate changes during treatment. A decrease may support an interpretation of reduced disease burden, whereas an increase may indicate possible progression, although small differences can reflect technical variation. The comparison therefore depends on consistent methods and attention to imaging conditions, not size alone.
Tumor measurements provide information about disease burden that can contribute to prognostic assessment and treatment evaluation. In clinical trials, standardized size data can serve as endpoints for comparing outcomes across participants or study periods. Consistent measurement and reporting are essential because unreliable differences could affect conclusions about treatment effects or disease behavior.