Tumor Size Monitoring

Tumor size monitoring is the repeated measurement of a tumor over time to assess disease status and guide medical decisions. Clinicians use imaging methods such as CT, MRI, or ultrasound to measure lesion dimensions or estimate volume, then compare standardized results across examinations while accounting for imaging conditions and anatomical changes. Increasing size may indicate progression, whereas reduction or stability can suggest treatment response or disease control, although size does not capture every biological change. In oncology, longitudinal measurements support diagnosis, therapy evaluation, surveillance, and clinical research by providing an objective outcome for comparing interventions.

Tumor Size Monitoring - Related Videos

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JoVE EoE - Neuroimaging

Morphological and Physiological Monitoring of Tumor Spheroids Using Optical Coherence Tomography

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2025

Source: Huang, Y. et. al., Longitudinal Morphological and Physiological Monitoring of Three-dimensional Tumor Spheroids Using Optical Coherence Tomography. J. Vis. Exp. (2019)This video demonstrates the use of optical coherence tomography (OCT) to monitor tumor spheroids in a multi-well plate by capturing high-resolution cross-sectional images. By analyzing light reflections from cellular structures, OCT constructs 3D models to assess morphological features like size and shape while also...

Research

JoVE Journal - Bioengineering
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Production of Large Numbers of Size-controlled Tumor Spheroids Using Microwell Plates

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Cited by 36 •

2013

We introduce a protocol for the generation of large numbers (thousands to hundreds of thousands) of uniform size- and composition-controlled tumor spheroids, using commercially available microwell plates.

PTM Based Tumor Microenvironment Monitoring: A Method for Tracking Changes in ECM Rigidity Using Tumor Spheroids

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2023

This protocol describes a technique for monitoring extracellular matrix rigidity changes by using particle-tracking microrheology (PTM). This is done by culturing 3D pancreatic tumor spheroids into ECM with embedded fluorescent probes for video particle-tracking and analysis.

An Orthotopic Model of Serous Ovarian Cancer in Immunocompetent Mice for in vivo Tumor Imaging and Monitoring of Tumor Immune Responses

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Cited by 18 •

2010

To study in vivo tumor growth and tumor microenvironment, we used a syngeneic and orthotopic mouse model of ovarian cancer in immunocompetent animals. We transduced a mouse tumor cell line (MOV1) with Katushka fluorescent protein (MOV1KAT) and here we show its orthotopic implantation in ovary and in vivo imaging.

Construction of a Preclinical Multimodality Phantom Using Tissue-mimicking Materials for Quality Assurance in Tumor Size Measurement

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Cited by 1 •

2013

This paper describes in-house procedures of constructing a preclinical multimodality phantom made of tissue-mimicking (TM) materials for quality assurance (QA) of tumor size measurement in animal imaging modalities such as ultrasound (US), computed tomography (CT) and magnetic resonance imaging (MRI).

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