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Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins

Article DOI: 10.3791/51789-v • 10:05 min • August 7th, 2014
August 7th, 2014 •
*1, *2, 1, 1, 1
1Center for Applied Proteomics and Molecular Medicine, George Mason University, 2Ceres Nanosciences
* These authors contributed equally

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요약
Automatic Translation

Several pathological biomarkers cannot be easily detected by current techniques because of their low concentration in biological fluids, the presence of degrading enzymes, and large amounts of high molecular weight proteins. Chemically functionalized hydrogel nanoparticles can harvest, preserve and concentrate low abundance proteins enabling the detection of previously undetectable biomarkers.

Tags

Hydrogel Nanoparticle Plasma Urine Low Abundance Proteins Biomarker Discovery Mass Spectrometry Immunoassays High-abundance Proteins Poly(N-isopropylacrylamide) Nanoparticles Capture Concentrate Preserve Biomarkers Low-molecular Weight Analytes Organic Chemical Dyes Protein Baits Concentration Factor Current Mass Spectrometers Western Blotting Immunoassays Enrichment Of Proteins And Peptides
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