Virginia Espina

Center for Applied Proteomics and Molecular Medicine, George Mason University

Research Area

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 11	2014
Publication title	2014

Other Publications

Article	Year
Protein microarrays: meeting analytical challenges for clinical applications. Cancer cell\| PubMed ID: 12726858	2003
Protein microarrays: molecular profiling technologies for clinical specimens. Proteomics\| PubMed ID: 14595807	2003
Proteomic profiling of the NCI-60 cancer cell lines using new high-density reverse-phase lysate microarrays. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14623978	2003
Molecular diagnostics. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program\| PubMed ID: 14633786	2003
Use of proteomic analysis to monitor responses to biological therapies. Expert opinion on biological therapy\| PubMed ID: 14680471	2004
Serum proteomics in cancer diagnosis and management. Annual review of medicine\| PubMed ID: 14746511	2004
Use of proteomic patterns to screen for gastrointestinal malignancies. Surgery\| PubMed ID: 14976472	2004
Clinical proteomics: revolutionizing disease detection and patient tailoring therapy. Journal of proteome research\| PubMed ID: 15113096	2004
Application of laser capture microdissection and protein microarray technologies in the molecular analysis of airway injury following pollution particle exposure. Journal of toxicology and environmental health. Part A\| PubMed ID: 15205040	2004
Protein microarray detection strategies: focus on direct detection technologies. Journal of immunological methods\| PubMed ID: 15261576	2004
Biomarkers of ovarian tumours. European journal of cancer (Oxford, England : 1990)\| PubMed ID: 15541961	2004
Genomic and proteomic technologies for individualisation and improvement of cancer treatment. European journal of cancer (Oxford, England : 1990)\| PubMed ID: 15541963	2004
Proteomic analysis of human breast cancer tissue with laser-capture microdissection and reverse-phase protein microarrays. Clinical breast cancer\| PubMed ID: 15585078	2004
Use of reverse phase protein microarrays and reference standard development for molecular network analysis of metastatic ovarian carcinoma. Molecular & cellular proteomics : MCP\| PubMed ID: 15671044	2005
Pathology of the future: molecular profiling for targeted therapy. Cancer investigation\| PubMed ID: 15779867	2005
Adipocyte-derived collagen VI affects early mammary tumor progression in vivo, demonstrating a critical interaction in the tumor/stroma microenvironment. The Journal of clinical investigation\| PubMed ID: 15841211	2005
Expression of xeroderma pigmentosum A protein predicts improved outcome in metastatic ovarian carcinoma. Cancer\| PubMed ID: 15844177	2005
Pegylated, steptavidin-conjugated quantum dots are effective detection elements for reverse-phase protein microarrays. Bioconjugate chemistry\| PubMed ID: 15898722	2005
Mapping molecular networks using proteomics: a vision for patient-tailored combination therapy. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 15908672	2005
CSF proteome: a protein repository for potential biomarker identification. Expert review of proteomics\| PubMed ID: 15966853	2005
An interventional magnetic resonance imaging technique for the molecular characterization of intraprostatic dynamic contrast enhancement. Molecular imaging\| PubMed ID: 15967127	2005
Manual exfoliation of fresh tissue obviates the need for frozen sections for molecular profiling. Cancer\| PubMed ID: 16015639	2005
A transforming growth factor-beta receptor-interacting protein frequently mutated in human ovarian cancer. Cancer research\| PubMed ID: 16061631	2005
Proteomic analysis of apoptotic pathways reveals prognostic factors in follicular lymphoma. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 16115925	2005
[Development of the protein microarray technique and usefulness in individualized molecular tumor therapy]]. Onkologie\| PubMed ID: 16205105	2005
Proteomic analysis of malignant ovarian cancer effusions as a tool for biologic and prognostic profiling. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 16467090	2006
Laser capture microdissection. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 16719357	2006
Accurate diagnosis of acute graft-versus-host disease using serum proteomic pattern analysis. Experimental hematology\| PubMed ID: 16728285	2006
Physicochemically modified silicon as a substrate for protein microarrays. Biomaterials\| PubMed ID: 16987550	2007
A phase II and pharmacodynamic study of gefitinib in patients with refractory or recurrent epithelial ovarian cancer. Cancer\| PubMed ID: 17330838	2007
Laser-capture microdissection. Nature protocols\| PubMed ID: 17406286	2006
Phosphoprotein pathway mapping: Akt/mammalian target of rapamycin activation is negatively associated with childhood rhabdomyosarcoma survival. Cancer research\| PubMed ID: 17409454	2007
The needle in the haystack: application of breast fine-needle aspirate samples to quantitative protein microarray technology. Cancer\| PubMed ID: 17487852	2007
A prospective analysis of imatinib-induced c-KIT modulation in ovarian cancer: a phase II clinical study with proteomic profiling. Cancer\| PubMed ID: 17559139	2007
Development of reverse phase protein microarrays for clinical applications and patient-tailored therapy. Cancer genomics & proteomics\| PubMed ID: 17878519	2007
Reverse-phase protein microarrays: application to biomarker discovery and translational medicine. Expert review of molecular diagnostics\| PubMed ID: 17892368	2007
Laser capture microdissection technology. Expert review of molecular diagnostics\| PubMed ID: 17892370	2007
Smart hydrogel particles: biomarker harvesting: one-step affinity purification, size exclusion, and protection against degradation. Nano letters\| PubMed ID: 18076201	2008
Reverse phase protein microarrays for monitoring biological responses. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 18217695	2007
Multiplexed cell signaling analysis of human breast cancer applications for personalized therapy. Journal of proteome research\| PubMed ID: 18257519	2008
Automated laser capture microdissection for tissue proteomics. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 18370312	2008
Reverse phase protein microarrays for theranostics and patient-tailored therapy. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 18370315	2008
Molecular network analysis using reverse phase protein microarrays for patient tailored therapy. Advances in experimental medicine and biology\| PubMed ID: 18593023	2008
A portrait of tissue phosphoprotein stability in the clinical tissue procurement process. Molecular & cellular proteomics : MCP\| PubMed ID: 18667411	2008
Laser capture microdissection and protein microarray analysis of human non-small cell lung cancer: differential epidermal growth factor receptor (EGPR) phosphorylation events associated with... Molecular & cellular proteomics : MCP\| PubMed ID: 18687633	2008
Core-shell hydrogel particles harvest, concentrate and preserve labile low abundance biomarkers. PloS one\| PubMed ID: 19274087	2009
Reverse-phase protein microarrays for theranostics and patient tailored therapy. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 19381949	2009
Application of laser microdissection and reverse-phase protein microarrays to the molecular profiling of cancer signal pathway networks in the tissue microenvironment. Clinics in laboratory medicine\| PubMed ID: 19389547	2009
Quantitative cell signalling analysis reveals down-regulation of MAPK pathway activation in colorectal cancer. The Journal of pathology\| PubMed ID: 19396842	2009
Anthrax infection inhibits the AKT signaling involved in the E-cadherin-mediated adhesion of lung epithelial cells. FEMS immunology and medical microbiology\| PubMed ID: 19416348	2009
Activated VEGF receptor shed into the vitreous in eyes with wet AMD: a new class of biomarkers in the vitreous with potential for predicting the treatment timing and monitoring response. Archives of ophthalmology\| PubMed ID: 19433709	2009
Comparison of global versus epidermal growth factor receptor pathway profiling for prediction of lapatinib sensitivity in bladder cancer. Neoplasia (New York, N.Y.)\| PubMed ID: 19881954	2009
The heme degradation pathway is a promising serum biomarker source for the early detection of Alzheimer's disease. Journal of Alzheimer's disease : JAD\| PubMed ID: 20157261	2010
Nanoparticle technology: amplifying the effective sensitivity of biomarker detection to create a urine test for hGH. Drug testing and analysis\| PubMed ID: 20355230	2009
Malignant precursor cells pre-exist in human breast DCIS and require autophagy for survival. PloS one\| PubMed ID: 20421921	2010
Concentration and Preservation of Very Low Abundance Biomarkers in Urine, such as Human Growth Hormone (hGH), by Cibacron Blue F3G-A Loaded Hydrogel Particles. Nano research\| PubMed ID: 20467576	2008
Nanoparticle technology: Addressing the fundamental roadblocks to protein biomarker discovery. Journal of materials chemistry\| PubMed ID: 20585471	2009
Tissue is alive: New technologies are needed to address the problems of protein biomarker pre-analytical variability. Proteomics. Clinical applications\| PubMed ID: 20871745	2009
Tumorigenic and metastatic activity of human thyroid cancer stem cells. Cancer research\| PubMed ID: 20959469	2010
Reverse phase protein microarrays advance to use in clinical trials. Molecular oncology\| PubMed ID: 20974554	2010
The use of hydrogel microparticles to sequester and concentrate bacterial antigens in a urine test for Lyme disease. Biomaterials\| PubMed ID: 21035184	2011
Functional protein network activation mapping reveals new potential molecular drug targets for poor prognosis pediatric BCP-ALL. PloS one\| PubMed ID: 21042412	2010
Reverse-phase phosphoproteome analysis of signaling pathways induced by Rift valley fever virus in human small airway epithelial cells. PloS one\| PubMed ID: 21072193	2010
What is the malignant nature of human ductal carcinoma in situ? Nature reviews. Cancer\| PubMed ID: 21150936	2011
A novel biomarker harvesting nanotechnology identifies Bak as a candidate melanoma biomarker in serum. Experimental dermatology\| PubMed ID: 21158936	2011
Breast cancer stem cells: a new target for therapy. Oncology (Williston Park, N.Y.)\| PubMed ID: 21361239	2011
Reverse phase protein microarrays: fluorometric and colorimetric detection. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 21370072	2011
One-step preservation of phosphoproteins and tissue morphology at room temperature for diagnostic and research specimens. PloS one\| PubMed ID: 21858221	2011
Phosphoprotein stability in clinical tissue and its relevance for reverse phase protein microarray technology. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 21901591	2011
Multifunctional core-shell nanoparticles: discovery of previously invisible biomarkers. Journal of the American Chemical Society\| PubMed ID: 21999289	2011
Reduction of preanalytical variability in specimen procurement for molecular profiling. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22081338	2012
Laser capture microdissection: Arcturus(XT) infrared capture and UV cutting methods. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22081345	2012
Improved data normalization methods for reverse phase protein microarray analysis of complex biological samples. BioTechniques\| PubMed ID: 22946677	2012
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy\| PubMed ID: 22966490	2012
Laser capture microdissection for protein and NanoString RNA analysis. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 23027006	2013
Molecular analysis of HER2 signaling in human breast cancer by functional protein pathway activation mapping. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 23045247	2012
Attacking breast cancer at the preinvasion stage by targeting autophagy. Women's health (London, England)\| PubMed ID: 23477322	2013
Elevated TNFR1 and serotonin in bone metastasis are correlated with poor survival following bone metastasis diagnosis for both carcinoma and sarcoma primary tumors. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 23493346	2013
Retinal pigment epithelium (RPE) exosomes contain signaling phosphoproteins affected by oxidative stress. Experimental cell research\| PubMed ID: 23669273	2013
Mapping protein signal pathway interaction in sarcoma bone metastasis: linkage between rank, metalloproteinases turnover and growth factor signaling pathways. Clinical & experimental metastasis\| PubMed ID: 23877430	2014
Application of Analyte Harvesting Nanoparticle Technology to the Measurement of Urinary HGH in Healthy Individuals. Journal of sports medicine & doping studies\| PubMed ID: 24014257	2012
Pathologic complete response after preoperative anti-HER2 therapy correlates with alterations in PTEN, FOXO, phosphorylated Stat5, and autophagy protein signaling. BMC research notes\| PubMed ID: 24304724	2013
Glioblastoma cell enrichment is critical for analysis of phosphorylated drug targets and proteomic-genomic correlations. Cancer research\| PubMed ID: 24346432	2013
Ductal carcinoma in situ: challenges, opportunities, and uncharted waters. American Society of Clinical Oncology educational book / ASCO. American Society of Clinical Oncology. Meeting\| PubMed ID: 24451705	2012
Stratification of clear cell renal cell carcinoma by signaling pathway analysis. Expert review of proteomics\| PubMed ID: 24575852	2014
Protein pathway analysis in Clinical Proteomics using protein microarrays. Drug discovery today. Technologies\| PubMed ID: 24982012	2005
Protein painting reveals solvent-excluded drug targets hidden within native protein-protein interfaces. Nature communications\| PubMed ID: 25048602	2014
Inhibition of Histone Deacetylase 4 Increases Cytotoxicity of Docetaxel in Gastric Cancer Cells. Proteomics. Clinical applications\| PubMed ID: 25091122	2014
Whole proteome analysis of mouse lymph nodes in cutaneous anthrax. PloS one\| PubMed ID: 25329596	2014
Reverse Phase Protein Arrays: Mapping the Path Towards Personalized Medicine. Molecular diagnosis & therapy\| PubMed ID: 25358623	2014