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Menneskelige pluripotent stamcelle Basert Utviklingstoksisitet Analyser for kjemikaliesikkerhet Screening og Systems Biology datagenerering

Article DOI: 10.3791/52333-v • 17:28 min • June 17th, 2015
June 17th, 2015 •
*1, *2, 1, 1, 1, 3, 3, 4, 2, 1, *2, *1
1Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne, 2Department of Biology, University of Konstanz, 3Department of Statistics, Technical University of Dortmund, 4Leibniz Research Centre for Working Environment and Human Factors, Technical University of Dortmund
* These authors contributed equally

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Protokollene beskriver to in vitro utviklingstoksisitetstestsystemer (UKK og UKN1) basert på humane embryonale stamceller og transkriptom studier. De testsystemer forutsi menneskelig utviklingstoksisitet farer, og kan bidra til å redusere dyrestudier, kostnader og den tiden som kreves for kjemisk sikkerhetstesting.

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Developmental Biology humane embryonale stamceller utviklingstoksisitet nevrotoksisitet neuroectodermal stamceller immunopresipitering differensiering cytotoksisitet embryopathy embryoid kroppen
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