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Journal / Cancer Research / マウス誘導多能性幹細胞由来腫瘍抗原特異的胸腺移民を生成する三次元胸腺培養システム…
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JoVE Journal Cancer Research
マウス誘導多能性幹細胞由来腫瘍抗原特異的胸腺移民を生成する三次元胸腺培養システム
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マウス誘導多能性幹細胞由来腫瘍抗原特異的胸腺移民を生成する三次元胸腺培養システム

Article DOI: 10.3791/58672-v • 10:44 min • August 9th, 2019
August 9th, 2019 •
*1,2, *1,2, 1,2, 1,2, 1,2, 1,2, 1,2, 1, 3, 1,2
1Surgery Branch, National Cancer Institute, NIH, 2Center for Cell-Based Therapy, National Cancer Institute, NIH, 3Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, NIH
* These authors contributed equally

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本論文では、三次元(3D)胸腺培養系により腫瘍抗原特異的誘導多能性幹細胞由来の甲状腺系(iTE)を生成する新しい方法について説明する。iTEは、増殖、記憶形成、腫瘍抑制の能力を有するナイーブT細胞と密接に関連するT細胞の均質なサブセットである。

Tags

がん研究,課題150,幹細胞,誘導多能性幹細胞,免疫学,養子細胞転移,T細胞分化,腫瘍抗原特異性,3D培養,胎児腺組織培養
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