a-three-dimensional-thymic-culture-system-to-generate-murine-induced

A Three-dimensional Thymic Culture System to Generate Murine Induced Pluripotent Stem Cell-derived Tumor Antigen-specific Thymic Emigrants

The inheritance of pre-rearranged T cell receptors (TCRs) and their epigenetic rejuvenation make induced pluripotent stem cell (iPSC)-derived T cells a ...

using-human-induced-pluripotent-stem-cells-for-generation-tumor

Using Human Induced Pluripotent Stem Cells for the Generation of Tumor Antigen-specific T Cells

The generation and expansion of functional T cells in vitro can lead to a broad range of clinical applications. One such use is for the treatment of ...

National Cancer Institute, NIH

Immunotherapy based on the adoptive transfer of naturally occurring or gene-engineered T cells can mediate tumour regression in patients with metastatic cancer. Here, we discuss progress in the use of adoptively transferred T cells, focusing on how they can mediate tumour cell eradication. Recent advances include more accurate targeting of antigens expressed by tumours and the associated vasculature, and the successful use of gene engineering to re-target T cells before their transfer into the patient. We also describe how new research has helped to identify the particular T cell subsets that can most effectively promote tumour eradication.

Adoptive immunotherapy for cancer: harnessing the T cell response.

Immunotherapies designed to trigger T cell destruction of tumor cells can result in sustained and complete responses in patients whose cancers were resistant to available treatment options. Evidence suggests that powering the T cell response - how T cells generate energy - plays an important role in their effectiveness. Furthermore the metabolism of T cells can be modulated to improve their anti-cancer activities. In this review, we will discuss the key metabolic properties of anti-cancer T cells, along with potential strategies to enhance immunotherapy through the modulation of T cell metabolism.

Metabolic reprograming of anti-tumor immunity.

Adaptive evolution has prompted immune cells to use a wide variety of inhibitory signals, many of which are usurped by tumor cells to evade immune surveillance. Although tumor immunologists often focus on genes and proteins as mediators of immune function, here we highlight two elements from the periodic table-oxygen and potassium-that suppress the immune system in previously unappreciated ways. While both are key to the maintenance of T-cell function and tissue homeostasis, they are exploited by tumors to suppress immuno-surveillance and promote metastatic spread. We discuss the temporal and spatial roles of these elements within the tumor microenvironment and explore possible therapeutic interventions for effective and promising anticancer therapies. .

ArticleTotal : 2	Year
Publication title Cited by 5	2019
Publication title Cited by 4	2019

Article	Year
Adoptive immunotherapy for cancer: harnessing the T cell response. Nature reviews. Immunology\| PubMed ID: 22437939	2012
Metabolic reprograming of anti-tumor immunity. Current opinion in immunology\| PubMed ID: 28412583	2017
Novel "Elements" of Immune Suppression within the Tumor Microenvironment. Cancer immunology research\| PubMed ID: 28576921	2017
Silencing stemness in T cell differentiation. Science (New York, N.Y.)\| PubMed ID: 29326263	2018

Nicholas P. Restifo

Biography

JoVE Journal Publications

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