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Immunology and Infection

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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Article DOI: 10.3791/59132-v • 04:23 min • April 28th, 2019
April 28th, 2019 •
1,2, 1,2, 1,2, 1,2, 1,2, 1,2, 1,2, 1,2,3
1Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, 2Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, 3Center of Infectious Disease and Signaling Research, National Cheng Kung University

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요약
Automatic Translation

Here, we present a protocol for creating an immunocompetent ICR (Institute of Cancer Research) murine model of central nervous system infection to display the development of neuropathy. Monitoring acute viral encephalitic disorders by identical disease scores could be performed for showing dengue virus-induced neuropathy in vivo.

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Murine Model Dengue Virus-induced Acute Viral Encephalitis-like Disease Disease Model In Vivo Platform Screening Viral And Host Vectors Neuropathogenesis Infection Procedure Viral Titer Immunocompetent Institute Of Cancer Research Suckling Mice Encephalitic-like Disease Procreation Induction Dilute Non-adapted Dengue Virus Plaque Forming Units RPMI 1640 Medium Concentration Syringe Intercerebral Delivery Lambda Area Sagittal And Lambdoid Suture Intraperitoneal Injection Scoring
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