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A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats

Article DOI: 10.3791/63502-v • 07:41 min • March 1st, 2022
March 1st, 2022 •
1,2,3, 1,2,3, 2, 2, 2,3, *2,3, *1,3,4
1Department of Cardiothoracic and Vascular Surgery, German Heart Center Berlin (DHZB), 2Institute of Physiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 3DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, 4Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
* These authors contributed equally

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요약
Automatic Translation

The present protocol describes a surgical procedure to remove ascending-aortic banding in a rat model of pulmonary hypertension due to left heart disease. This technique studies endogenous mechanisms of reverse remodeling in the pulmonary circulation and the right heart, thus informing strategies to reverse pulmonary hypertension and/or right ventricular dysfunction.

Tags

Reverse Vascular Remodeling Pulmonary Hypertension Left Heart Disease Aortic Debanding Rat Model Surgical Procedure Pulmonary Circulation Right Ventricle Physiological Reverse Remodeling Treating Pulmonary Hypertension Anesthesia Sterilized Surgical Table Adhesive Tape Povidone-iodine/iodophor Solution Tracheotomy Cervical Midline Incision Fine Scissors Infrahyoid Muscles Tracheal Cannula
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