Alternative models for nanomaterial hazard assessment
Shareen Doak is a Professor of Genotoxicology and Cancer in Swansea University Medical School where she leads the In…
University of Fribourg
Prof. Dr. Barbara Rothen-Rutishauser has received her doctorate in cell biology from the Swiss Federal Institute of…
There is a need to provide hazard assessment tests for the early stage of development in pharmaceutical, cosmetic, and chemical industries to support both product selection, and later, regulatory approvals. This can be more challenging for products based on nanomaterials as their behavior in biological compartments can differ from traditional chemical compounds. Therefore, intensified efforts have been made during recent years towards a systematic development and evaluation of innovative and more reliable non-animal models. The variety of in silico and in vitro methods is broad and range from physiologically based pharmacokinetic modeling, to two-dimensional (2D) cell cultures, and to increasingly complex 3D cell cultures and co-cultures representing a more realistic physiological situation. The focus of this special issue will be to show how such advanced models can be reproducibly generated, characterized and applied for nanomaterial hazard assessment purposes.