Myopia is a highly prevalent chronic progressive ocular condition that is rapidly growing into a public health epidemic. It has been estimated that, by 2050, the worldwide prevalence of myopia will rise to 50%. Myopia occurs due to dysregulated eye growth that produces a mismatch in the eye’s optical power and axial length leading to blurry distance vision. Excessive eye elongation in myopia also stretches the ocular tissues, predisposing the eye to sight-threatening ocular pathologies that can lead to irreversible blindness.

Over the years, the scientific and clinical communities have devoted significant efforts towards understanding the etiological basis of myopia and identifying ways to control its onset and progression. In this endeavor, investigators have studied several animal models ranging from invertebrates to humans and have implemented a broad spectrum of experimental and clinical research methods. These research efforts have had a significant impact, paving the way for an improved understanding of the eye growth regulatory processes and myopia mechanisms and stimulating the development of optical, pharmacological, and environmental strategies for the control of childhood myopia.

The objective of this Collection is to synthesize the broad range of experimental and clinical methods used in basic, clinical, and translational myopia research. We hope that the evidence-based collection of contemporary myopia research methods will facilitate knowledge sharing across clinics and laboratories, encourage the utilization of trans-disciplinary techniques, and promote collaborative opportunities for clinicians and scientists devoted to different facets of the myopia realm, ultimately leading to rapid advances in the field of myopia.