Methods Collections
Rabies is an acute progressive encephalitis caused by a lyssavirus. The case fatality of this zoonosis is the highest for any infectious disease. Although laboratory tech…
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The Mexican Tetra, Astyanax mexicanus is an excellent model organism to study the developmental and genetic basis of evolution. This species of fish co…
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Chloroplasts are the organelles that define plants. Along with many other metabolic, developmental and signalling functions, chloroplasts are responsible for photosynthes…
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The study of protein-protein interactions is key to understanding the network of molecular interactions underlying biological effects, and defining how individual protein…
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Integrative structural biology uses a large variety of biophysical methods that provide detailed knowledge of the atomic and molecular structure of macromolecules, isolat…
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Prolonged lifespan and delayed childbearing have prompted the research of reliable methods to preserve fertility for later in life. Such interventions that heavily rely o…
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Interdisciplinary problems are increasingly important to researchers from all fields. Due to their multidisciplinary characteristics, such studies should be performed in …
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Advancements in ultrasound transducer and computer technology have permitted for the visualization of cardiac structures with excellent spatial and temporal resolution in…
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Cell-free expression (CFE) systems are a collection of methods that use extracted cellular machinery to mimic core functions of cells, such as transcription and translati…
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The vertebrate retina is a complex, laminated sensory organ. It consists of multiple neuronal cell types and subtypes which synapse on each other to detect visual informa…
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The sense of taste is essential to preserve a healthy body and mind. While taste contributes to the selection of beneficial compounds over noxious compounds to ensure pro…
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Proteins adopt different higher order structures (HOS) to enable their unique biological functions. Understanding the complexities of protein higher order structures and …
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The study of gastrointestinal inflammation and repair is key to elucidate the role of different cell populations and molecules during acute and chronic gut inflammatory p…
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Covering ~40% of the human body, skeletal muscle is a major organ, supporting critical functions ranging from movement and respiration, to metabolism and temperature regu…
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Recent years have seen rapid development of electron microscopy techniques for a variety of fields. The physical sciences, in particular, have seen a large number of tech…
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In vitro culture is a powerful tool for the phenotypic and mechanistic study of retinal function and cellular activities. Classical 2D primary endothelial cell function a…
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The genomics revolution has resulted in a vast amount of knowledge about human physiology and how different diseases affect function. Additional technological advancement…
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Obesity has become a major worldwide public health issue, dramatically increasing the risk of developing cardiovascular disease, type 2 diabetes, and liver diseases. Obes…
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The number of manufactured nanomaterials (MNMs) entering the market in everyday products is continuously increasing. These products range from health care to electronics,…
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Acute hippocampal slices have been used for decades by neuroscientists to study neuronal circuits and synaptic properties. This technique has yielded major discoveries, s…
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Cancer research has focused on the cancer cell, its proliferation rates, apoptosis resistance, mutation rates, sensitivity to radio and chemotherapy. However, tumor metas…
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Neurons are the primary cells of the nervous system and are responsible for the distinctive roles of the brain. Understanding the mechanisms that regulate their different…
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Protein homeostasis, or ‘proteostasis’, is fundamental to cellular and organismal health. Conserved cellular processes cooperate to maintain a properly folded…
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Neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and frontotemporal d…
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Cardiovascular diseases remain a major health and economic burden worldwide. This is a consequence to the poor regenerative ability of the adult mammalian heart to repair…
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Axons are the main line of information transmission among neurons. Accordingly, axonal pathology represents a common pathogenic feature associated with loss of neuronal c…
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Pluripotent stem cells retain the ability to form all cell types in the human body. This provides the field with renewable forms of human tissue, from defined genetic bac…
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Minimally invasive pancreatic surgery is on the rise worldwide. Minimally invasive distal pancreatectomy (MIDP) has been reported to be superior to open distal pancreatec…
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Organoids are three-dimensional (3D) ex vivo cellular structures that are believed to recapitulate and maintain the in vivo conditions of cellular viability and responsiv…
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International classifications of mental disorders for the diagnosis of Learning Disabilities (LD) and Attention Deficit/Hyperactivity Disorders (ADHD) establish that they…
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Nanogels are hydrogels within the nanometres range consisting of crosslinked porous polymer networks with the ability to retain high volumes of water or biological fluids…
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Fungi play vital ecological roles in nature as major nutrient recyclers, establish mutualistic relationships with other organisms, and cause devastating diseases of plant…
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