The global pork industry is an innovation-driven sector that continually integrates scientific and technological progress to optimize animal health, welfare, and production efficiency. Modern swine systems already employ sophisticated management, genetic selection, nutritional strategies, and health monitoring to ensure high standards of care, productivity and food safety. As the industry continues to evolve in response to emerging scientific knowledge and societal expectations, further strengthening animal welfare, health, and resilience represents an opportunity to enhance both biological performance and long-term sustainability. A deeper understanding of how biological, environmental, and management factors interact to influence resilience and welfare will support ongoing innovation and help ensure the continued success and responsible advancement of pork production worldwide.

Despite substantial progress, key challenges persist, including the impact of intensive production systems on stress adaptation, immune response to pathogens, and specific needs across different life stages, alongside the ongoing threat of emerging infectious diseases, antimicrobial resistance, and climate-related stressors. Limited standardization in welfare assessment, gaps in translating omics and systems biology insights into applied management, and insufficient integration of host–pathogen interaction research into resilience frameworks further constrain advances in herd health and stability across diverse production environments.

This Collection aims to provide an interdisciplinary platform for original research articles, review articles, and method-focused studies that explore the biological, environmental, technological, and epidemiological determinants of swine welfare, health, and resilience. Contributions addressing immune responses, host–pathogen interactions, disease preparedness, behavioral indicators, nutrition, genetics, microbiome dynamics, housing systems, and precision livestock innovations will be particularly relevant within the scope of this Collection.

Overall, this Collection will facilitate knowledge integration, promote evidence-based best practices, and accelerate the development of resilient, welfare-oriented swine production systems aligned with future agricultural and societal needs.