Affiliation: Harvard Medical School

Dr. Alexandre G. Lellouch is a Board-certified plastic surgeon in Paris and co-investigator / Lecturer at MGH/ Harvard. He has extensive experience in reconstructive microsurgery. The hand and face transplantation as clinical options in the treatment of severely injured and disfigured patients led led him to dive into the field of reconstructive transplantation. Vascularized Composite allotransplantation (VCA) has emerged in recent years as the most promising treatment option for many patients afflicted with soft tissue defects that cannot be satisfactorily reconstructed using contemporary techniques. Moreover, VCA has overtaken tissue engineering by becoming a clinically viable option. Unfortunately, the prognostic in the long term is compromised due to the ineluctable development of chronic rejection and the absence of treatment available. To overcome this issue, Dr. Lellouch’s team focuses on decellularization technologies, machine perfusion, and immune tolerance induction protocols.