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Methods Collections > Prostate organoid research techniques and methods: three-dimensional (3D) culture, spin-down, dimpled parafilm and fusion method

Christina Jamieson

Affiliation: University of California San Diego

Dr. Jamieson is a translational scientist in Urologic Oncology, in the Department of Urology, University of California, San Diego (UCSD). She investigates the causes of bone metastasis and has established new patient sample derived models to test new therapies and offer hope to patients with advanced, castration resistant prostate cancer. She obtained her PhD in Molecular Immunology at Brandeis University with Dr. Ranjan Sen and showed that T cell receptor (TCR) stimulation itself induced NF-kB activation and NF-AT. Dr. Jamieson moved to the University of California, San Francisco (UCSF) for her post-doctoral fellowship, first with Dr. Dan R. Littman and then with Dr. Keith R. Yamamoto. She uncovered mechanisms of signaling crosstalk between TCR and glucocorticoids that regulate the survival of T cell progenitors, thus shaping the immune repertoire. These pathways can also be dysregulated in steroid hormone-driven cancers.  Dr. Jamieson began as an Assistant Professor in the Depts. Of Urology and Human Genetics at UCLA to investigate mechanisms of resistance to steroid hormone-based therapy in cancer then moved to UCSD to focus on how to overcome therapy-resistance in bone metastatic prostate cancer using patient samples-based models and new therapies.

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