Affiliation: University of Pennsylvania

Andrey Tvardovskiy, PhD, is an assistant professor in the Department of Biochemistry and Biophysics and a core member of the Epigenetics Institute at the University of Pennsylvania (UPenn). His research integrates chromatin biology, proteomics, and aging. He focuses on understanding how lifelong changes in the landscape of histone modifications and chromatin protein composition affect genome function and contribute to age-related decline.

Dr. Tvardovskiy earned his PhD in Biochemistry and Molecular Biology from the University of Southern Denmark, where he developed and applied mass spectrometry-based approaches for the quantitative profiling of combinatorial histone modifications. His doctoral work provided pioneering insights into the complexity and age-associated changes in histone modification patterns. During his postdoctoral training at the Helmholtz Center Munich, he investigated how nuclear proteins decode complex chromatin modification signatures to regulate genome function.

At UPenn, the Tvardovskiy Lab integrates advanced mass spectrometry, genomics, and biochemical tools to dissect chromatin-based regulatory circuits and uncover the mechanisms underlying their deterioration during aging.