Cellular Signaling
Cellular Signaling - Related Videos
10:33
Local Field Fluorescence Microscopy: Imaging Cellular Signals in Intact Hearts
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Cited by 8 •
2017
In the heart, molecular events coordinate the electrical and contractile function of the organ. A set of local field fluorescence microscopy techniques presented here enables the recording of cellular variables in intact hearts. Identifying mechanisms defining the cardiac function is critical in understanding how the heart works under pathological situations.
10:03
Rapid and Robust Analysis of Cellular and Molecular Polarization Induced by Chemokine Signaling
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Cited by 4 •
2014
Chemokine signaling elicits marked alterations of cellular morphology and some important redistributions of intracellular proteins. Here, a rapid and detailed protocol is provided to study these events.
14:55
Integrative Toolkit to Analyze Cellular Signals: Forces, Motion, Morphology, and Fluorescence
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Cited by 7 •
2022
The Integrative Toolkit to Analyze Cellular Signals (iTACS) platform automates the process of simultaneously measuring a wide variety of chemical and mechanical signals in adherent cells. iTACS is designed to facilitate community-driven development and enable researchers to use all platform features regardless of their educational background.
08:45
Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors
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Cited by 4 •
2020
The ability to assess target engagement by candidate inhibitors in intact cells is crucial for drug discovery. This protocol describes a 384 well format cellular thermal shift assay that reliably detects cellular target engagement of inhibitors targeting either wild-type SHP2 or its oncogenic variants.
05:00
Cellular Respiration - Concepts
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2019
Autotrophs and Heterotrophs Living organisms require a continuous input of energy to maintain cellular and organismal functions such as growth, repair, movement, defense, and reproduction. Cells can only use chemical energy to fuel their functions, therefore they need to harvest energy from chemical bonds of biomolecules, such as sugars and lipids. Autotrophic organisms, namely plants, algae, and photosynthetic and chemosynthetic bacteria, convert inorganic materials into such biomolecules by...
FAQs
Receptor location determines where a signal first enters the cell’s regulatory network. Cell-surface receptors respond to signals detected outside the cell, whereas intracellular receptors respond to signals that reach the cell interior. These starting points can engage different molecular events, including second-messenger activity, protein phosphorylation cascades, or changes in gene expression, producing responses suited to the incoming information.
Second messengers and protein phosphorylation help transmit information from an activated receptor to downstream cellular processes. A second messenger carries the signal within the cell, while phosphorylation changes the activity of proteins in a signaling cascade. Together, these molecular steps can connect receptor activation with altered metabolism, movement, growth, differentiation, or gene expression.
Signaling pathways coordinate cell behavior by linking detected information to specific biological outcomes. Their activity can influence whether cells grow, differentiate, move, alter metabolism, or undergo programmed cell death. This regulation allows cells to respond to changing conditions while maintaining coordination within tissues, making signaling control central to normal biological function.
Researchers examine cellular signaling to understand how cells regulate growth, differentiation, metabolism, movement, and programmed cell death. These processes represent distinct outcomes that can arise from molecular events after receptor activation. Studying their connections helps biology explain how individual cellular responses contribute to coordinated tissue function and adaptation to changing conditions.
Disrupted communication between cells can interfere with the regulation of essential processes such as growth, differentiation, metabolism, movement, or programmed cell death. Cellular signaling research therefore helps explain disease mechanisms by connecting abnormal molecular communication with altered biological behavior. This perspective is especially relevant when disease reflects failures in coordination between cells or tissues.
Understanding signaling pathways can identify molecular events associated with abnormal cellular behavior and disease. That knowledge supports targeted therapies designed around disrupted communication rather than treating every cellular process indiscriminately. In biology and medicine, examining receptors, second messengers, phosphorylation cascades, and gene-expression changes can therefore connect disease mechanisms with more focused therapeutic strategies.