Placental Vascular Network
Placental Vascular Network - Related Videos
09:33
Three-dimensional Rendering and Analysis of Immunolabeled, Clarified Human Placental Villous Vascular Networks
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Cited by 12 •
2018
This study presents a protocol for the reversible tissue clearing, immunostaining, 3D-rendering and analysis of vascular networks in human placenta villi samples on the order of 1 - 2 mm3.
03:33
Visualization of Neural and Vascular Networks in a Chicken Embryo
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2025
Source: Delalande, J., et.al. Dual Labeling of Neural Crest Cells and Blood Vessels Within Chicken Embryos Using ChickGFP Neural Tube Grafting and Carbocyanine Dye DiI Injection. J. Vis. Exp. (2015)This video demonstrates the transplantation of a GFP-labeled donor neural tube from a stage-matched transgenic chicken embryo into a recipient embryo at the level of somites one to seven, followed by vascular labeling using a lipophilic fluorescent dye. The combined approach allows for direct...
10:53
Image-guided, Laser-based Fabrication of Vascular-derived Microfluidic Networks
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Cited by 10 •
2017
This protocol outlines the implementation of image-guided, laser-based hydrogel degradation to fabricate vascular-derived, biomimetic microfluidic networks embedded in poly(ethylene glycol) diacrylate (PEGDA) hydrogels. These biomimetic microfluidic systems may be useful for tissue engineering applications, generation of in vitro disease models, and fabrication of advanced "on-a-chip" devices.
07:04
Human Placental and Decidual Organ Cultures to Study Infections at the Maternal-fetal Interface
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Cited by 7 •
2016
A simple method to establish primary human placental (villous) and decidual organ cultures is described. Villous and decidual organ cultures are invaluable tools for studying pathogenesis at the human maternal-fetal interface. Infection with the facultative intracellular bacterium Listeria monocytogenes is demonstrated.
12:17
The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
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Cited by 18 •
2017
We present a detailed method to study human placental physiology in vivo at term. The method combines blood sampling from the incoming and outgoing vessels on the maternal and fetal sides of the placenta with ultrasound measurements of volume blood flow and placental tissue sampling.
FAQs
Angiogenesis extends the fetal vessel system through the chorionic villi, while vascular remodeling reorganizes that system as placental structure changes. These processes are complementary: new vessel growth increases the network’s reach, and remodeling adjusts its organization within developing tissue. Together, they help maintain close access to maternal blood for exchange without merging the fetal and maternal circulations.
Vessel distribution within the chorionic villi brings fetal blood close to maternal blood, which supports the transfer of oxygen and nutrients and the removal of carbon dioxide and waste. The arrangement achieves proximity for exchange while preserving separate fetal and maternal circulatory systems. This spatial organization is therefore central to how the placenta supports the developing fetus.
As the placenta grows, its vascular network must extend and reorganize within the developing chorionic villi. Angiogenesis increases the extent of fetal vessels, while remodeling changes their organization to match the expanding placental structure. This continuing adjustment helps the network support exchange demands throughout development rather than remaining a fixed arrangement.
Its formation and organization provide a model for studying how blood vessels develop within a growing organ and how tissue structure supports exchange. Developmental biologists can relate vascular growth and remodeling to placental function and fetal growth. The network also offers context for understanding how disrupted blood flow or abnormal vascular development may affect pregnancy.
Examining vascular organization helps researchers connect the architecture of fetal vessels with the placenta’s ability to deliver oxygen and nutrients and remove waste. It also supports interpretation of fetal growth in relation to placental development. Because impaired blood flow and abnormal vascular development are associated with pregnancy complications, organization provides an important developmental context for those conditions.
Abnormal vascular development or impaired blood flow can be examined as potential explanations for altered placental function and restricted support of fetal growth. Studying these changes places pregnancy complications within a developmental framework, linking vessel formation and remodeling to exchange capacity. This approach helps clarify why normal vascular development is important for maintaining the placenta’s role during pregnancy.