Ocular Complications

Ocular complications are disorders or injuries affecting the eye and visual system that arise from systemic disease, local pathology, trauma, infection, or medical treatment, and they matter because they can threaten vision and signal broader health problems. They develop through mechanisms such as inflammation, vascular injury, altered intraocular pressure, tissue degeneration, or medication toxicity, which can disrupt the cornea, lens, retina, optic nerve, or surrounding tissues. In medicine, recognizing these complications through history-taking, eye examination, and appropriate imaging supports early diagnosis, risk assessment, and targeted management while helping clinicians monitor treatment safety and prevent avoidable visual impairment.

Ocular Complications - Related Videos

Research

JoVE Journal - Medicine
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Experimental Glaucoma Induced by Ocular Injection of Magnetic Microspheres

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Cited by 25 •

2015

We present a method for inducing elevated intraocular pressure (IOP), by injecting magnetic microspheres into the rat eye, to model glaucoma. This leads to strong pressure rises, and extensive neuronal death. This protocol is easy to perform, does not require repeat injections, and produces stable long-lasting IOP rises.

Research

JoVE EoE - Immune Response

A Method to Induce Ocular Surface Inflammation in a Murine Model

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2025

This video demonstrates a method to induce ocular surface inflammation and meibomian gland dysfunction in a murine model. Stimulation of the mouse's immune system using an immunogen and later restimulation with the same immunogen promotes ocular surface inflammation, which causes plugging of meibomian gland secretion through neutrophil-produced aggNETs and leads to dry eye disease.

Education

JoVE Core - Pathophysiology

Healing II: Complications

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2026

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...

Laser-Induced Chronic Ocular Hypertension Model on SD Rats

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Cited by 26 •

2007

Glaucoma is one of the major causes of blindness in the world. Elevated intraocular pressure is a major risk factor. Laser photocoagulation induced ocular hypertension is one of the well established animal models. This video demonstrates how to induce ocular hypertension by Argon laser photocoagulation in rat.

Intravitreous Injection for Establishing Ocular Diseases Model

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Cited by 36 •

2007

Intravitreous injection is a widely used technique in visual sciences research for ocular diseases or as direct application of local treatment. This video demonstrated a protocol for intravitreous injection using a 1ml syringe with glass pipette. Useful tips about avoiding massive bleeding and lens damage are given.

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