Behavioral Pharmacology

Behavioral pharmacology is the study of how drugs and other chemical compounds alter behavior, linking observable actions to activity in the nervous system. Researchers assess effects on processes such as learning, motivation, movement, and reward by administering controlled doses and measuring responses in tasks designed to model specific behavioral functions; dose, timing, and prior experience can shape these outcomes. In neuroscience, this approach helps identify drug targets and clarify how neurotransmitter systems contribute to behavior. It also supports preclinical evaluation of treatments for substance use, psychiatric, and neurological disorders, while informing research on drug effects, dependence, and potential adverse outcomes.

Behavioral Pharmacology - Related Videos

Research

JoVE Journal - Behavior

Automated, Quantitative Cognitive/Behavioral Screening of Mice: For Genetics, Pharmacology, Animal Cognition and Undergraduate Instruction

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Cited by 18 •

2014

Fully automated system for measuring physiologically meaningful properties of the mechanisms mediating spatial localization, temporal localization, duration, rate and probability estimation, risk assessment, impulsivity, and the accuracy and precision of memory, in order to assess the effects of genetic and pharmacological manipulations on foundational mechanisms of cognition in mice.

Research

JoVE Journal - Behavior
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Behavioral Phenotyping of Murine Disease Models with the Integrated Behavioral Station (INBEST)

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Cited by 4 •

2015

Prolonged and comprehensive monitoring of mice in a home-cage environment provides a deeper understanding of aberrant behavior in murine models of brain diseases. This paper describes the Integrated Behavioral Station (INBEST) as the key component of contemporary behavioral analysis.

Fat Preference: A Novel Model of Eating Behavior in Rats

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Cited by 9 •

2014

Dietary fat content influences both energy intake and body fat composition in mammals. By examining rats’ preference for high fat food in a series of choice experiments, it is possible to test genetic differences and pharmacological interventions on their preference for high fat food.

Research

JoVE Journal - Biology
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Pharmacological and Functional Genetic Assays to Manipulate Regeneration of the Planarian Dugesia japonica

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Cited by 17 •

2011

An attractive model for studying stem cell differentiation within a live animal is the planarian flatworm. Regeneration is studied by simple amputation experiments that are easily performed in a basic laboratory and are amenable to pharmacological and genetic (in vivo RNAi) manipulation as detailed by protocols in this article.

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention

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Cited by 23 •

2013

Loss of the righting reflex has long served as a standard behavioral surrogate for unconsciousness, also called hypnosis, in laboratory animals. Alterations in volatile anesthetic sensitivity caused by pharmacological interventions can be detected with a carefully controlled high-throughput assessment system, which may be adapted for delivery of any inhaled therapeutic.

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