C57 Mice
C57 Mice - Related Videos
01:52
Inducing Hearing Loss in Mice Through Prolonged High-Volume Sound Exposure
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2025
Source: Lee, D. et. al., Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage. J. Vis. Exp. (2023)This video demonstrates the procedure of noise-induced hearing loss in mice. High-volume sound damages hair cells in the inner ear and disrupts auditory pathways, resulting in hearing impairment.
08:44
Activating Autophagy by Aerobic Exercise in Mice
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Cited by 37 •
2017
Autophagy activation is beneficial in the prevention of a number of diseases. One of the physiological approaches to induce autophagy in vivo is physical exercise. Here we show how to activate autophagy by aerobic exercise and measure autophagy levels in mice.
08:06
Use of a Low-flow Digital Anesthesia System for Mice and Rats
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Cited by 4 •
2016
Here, we present a protocol to more safely and efficiently administer anesthetic gas to mice using a digital, low flow anesthesia system utilizing a syringe-driven direct injection vaporizer.
08:45
Polygraphic Recording Procedure for Measuring Sleep in Mice
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Cited by 55 •
2016
The recording of electroencephalogram (EEG) and electromyogram (EMG) in freely behaving mice is a critical step to correlate behavior and physiology with sleep and wakefulness. The experimental protocol described herein provides a cable-based system for acquiring EEG and EMG recordings in mice.
02:46
Intranasal Murine Herpesvirus Infection in Mice to Assess Host Immune Responses
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2026
Source: Zhang, J., et al. P. Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production. J. Vis. Exp. (2014)This video demonstrates intranasal delivery of murine herpesvirus in mice to induce a lung-specific immune response. Lung tissue is subsequently processed to obtain cytokine-containing supernatants for downstream assessment of host immune responses.
FAQs
Near-homozygosity limits genetic variation between animals, which can make neural and behavioral measurements more reproducible. This consistency helps researchers attribute differences in learning, memory, disease-related phenotypes, or treatment responses to the experimental manipulation rather than broad background variation. However, genetic uniformity does not eliminate strain-specific biological traits, so results still require careful interpretation.
Sub-strain differences can influence gene expression, sensory function, metabolism, and behavior. These traits may alter baseline neural phenotypes or modify how animals respond to genetic and pharmacological interventions. Consequently, findings obtained with one C57 sub-strain should not automatically be generalized to another without considering whether the relevant physiological or behavioral characteristics are comparable.
Age, sex, housing conditions, and sub-strain can each affect behavioral and physiological outcomes. These variables may change the apparent severity of a neural phenotype or the measured response to an intervention. Keeping them consistent, balancing them across experimental groups, and reporting them clearly helps distinguish treatment-related effects from variation associated with the animals’ biological or living conditions.
A measured behavior may reflect more than the neural process under investigation because C57 mice have strain-specific sensory and metabolic characteristics. Such differences can influence performance and physiological responses, potentially making a learning, memory, pain, or treatment result appear stronger or weaker. Researchers therefore need to interpret behavioral findings alongside the relevant strain characteristics and experimental conditions.
Before beginning an experiment, researchers should specify the C57 sub-strain and define the age, sex, and housing conditions to be used. They should also consider whether the study focuses on learning and memory, neurodegenerative disease, neural circuits, pain, or an intervention response. Matching these choices to the research question improves reproducibility and clarifies how broadly findings may apply.
C57 mice support studies of learning and memory, neurodegenerative disease, neural circuits, pain, and genetic or pharmacological interventions. Experiments can examine neural phenotypes, behavioral performance, disease-related changes, or responses to treatment within a controlled genetic background. The resulting data are most informative when researchers account for strain-specific traits and report the animal characteristics that may shape outcomes.