High-contrast Thrombus Detection
High-contrast Thrombus Detection - Related Videos
08:50
Thrombus Profiling Assay: A Microfluidics-Based Platform for Comprehensively Characterizing Biomechanical Thrombogenesis
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2026
This work describes a microfluidic assay that uses shear stress to trigger thrombus formation in blood and characterizes the thrombus by multiple dimensions of readout. The assay can measure the prothrombotic tendency of blood samples, and is thus useful in disease diagnosis, drug discovery, as well as basic mechanistic studies related to thrombosis.
09:01
Intravital Microscopy and Thrombus Induction in the Earlobe of a Hairless Mouse
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Cited by 4 •
2017
The ear model of the hairless SKH1-Hrhr mouse enables intravital fluorescence microscopy of microcirculation and phototoxic thrombus induction without prior surgical preparation in the examined microvascular bed. Therefore, the ear of the hairless mouse is an excellent in vivo model to study the complex interactions during microvascular thrombus formation, thrombus evolution, and thrombolysis.
05:54
Intravital Fluorescence Microscopy to Study Microvascular Thrombus Formation
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2025
This video demonstrates the intravital fluorescence microscopy technique to study thrombus formation in a mouse model. The mouse is injected with a fluorophore-labeled polysaccharide to monitor blood circulation. Upon illumination with a high-intensity light, the phototoxic induction of an injury in the microvasculature of the ear leads to the formation of a thrombus, which is confirmed by visualizing the obstruction in the blood flow.
02:05
Visualization of a Cerebral Thrombus in a Mouse Using Micro-Computed Tomography Imaging
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2025
Source: Kim, D., et. al. Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli. J. Vis. Exp. (2016)This video demonstrates visualization of cerebral thrombus in mice using micro-computed tomography (micro-CT) imaging. A cerebral thrombus mouse model is injected with fibrin-targeted gold nanoparticles acting as a contrasting agent. The mouse is placed on the bed of a micro-CT machine, and images are acquired from multiple angles.
11:18
Real-time Imaging of Heterotypic Platelet-neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice
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Cited by 29 •
2013
Here we report an experimental technique of fluorescence intravital microscopy to visualize heterotypic platelet-neutrophil interactions on the activated endothelium during vascular inflammation and thrombus formation in live mice. This microscopic technology will be valuable to study the molecular mechanism of vascular disease and to test pharmacologic agents under pathophysiological conditions.
FAQs
The useful contrast may arise from differences between the thrombus and circulating blood, the vessel wall, or nearby tissue. Each surrounding structure provides a different visual reference, so conspicuity depends on how clearly the clot separates from its immediate environment. This distinction helps readers recognize the thrombus rather than confusing it with normal vascular anatomy.
Locating a clot relative to the vessel lumen helps clarify whether it occupies or narrows the space through which blood flows. That spatial information adds meaning beyond simply seeing an abnormal signal or region. In neuroscience, it supports interpretation of cerebral vascular obstruction and helps connect the clot’s position with possible effects on blood flow.
Greater conspicuity can make the boundaries and position of a thrombus easier to inspect against blood, vessel walls, and surrounding tissue. This may reduce uncertainty when determining where the clot begins and ends or how it relates to the lumen. The resulting image interpretation can support more consistent evaluation of vascular disease and occlusion.
Clarity depends on the contrast difference between the thrombus and the structures around it. Blood, vessel walls, and adjacent tissue can each provide a distinct or challenging background for interpretation. The location and extent of the clot also matter because they determine how its appearance relates to the vessel lumen and the surrounding vascular anatomy.
A practical evaluation begins with reviewing the vascular image for a conspicuous clot, then identifying its location, estimating its extent, and examining its relationship to the vessel lumen. Investigators can next consider how the apparent occlusion relates to blood-flow effects. This sequence organizes image interpretation without treating visibility alone as a complete assessment.
The approach is relevant when investigators need to recognize cerebral thrombi, assess vascular disease, or study how occlusions affect blood flow. It can support stroke assessment and broader investigations of thrombosis by making clot-related findings easier to analyze. These uses also contribute to evaluating and developing diagnostic imaging methods for neurovascular conditions.