Swelling Induced Buckling

Swelling-induced buckling is the formation of wrinkles, folds, or other out-of-plane patterns when a material expands unevenly during solvent or fluid absorption. Differential swelling generates compressive stress, and once that stress exceeds the structure’s stability threshold, the material relieves it through geometric deformation rather than continued in-plane expansion. The resulting patterns depend on swelling gradients, elastic stiffness, layer thickness, and mechanical constraints. Studying this instability helps explain shape changes in hydrogels, polymer films, soft composites, and biological tissues, while supporting the design of stimuli-responsive surfaces, flexible devices, microfluidic components, and engineered materials with controllable architectures.

Swelling Induced Buckling - Related Videos

Education

JoVE Science Education - Engineering

Buckling of Steel Columns

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2023

Source: Roberto Leon, Department of Civil and Environmental Engineering, Virginia Tech, Blacksburg, VA In the design of civil works, it is important to deliver structures that are not only safe under unexpected loads, but also provide excellent performance under everyday loads at a reasonable economic cost. The latter is often tied to minimum use of materials, ease of fabrication, and rapid construction in the field. Structures made of steel members can be very economical because of the great...

Research

JoVE Journal - Medicine

Forskolin-induced Swelling in Intestinal Organoids: An In Vitro Assay for Assessing Drug Response in Cystic Fibrosis Patients

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Cited by 121 •

2017

This protocol describes an assay for measuring CFTR function and CFTR modulator responses in cultured tissue from subjects with cystic fibrosis (CF). Biopsy-derived intestinal organoids swell in a cAMP-driven fashion, a response that is defective (or strongly reduced) in CF organoids and can be restored by exposure to CFTR modulators.

Mitochondrial Ca2+ Retention Capacity Assay and Ca2+-triggered Mitochondrial Swelling Assay

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Cited by 11 •

2018

This protocol aims to describe a method to examine the Ca2+ retention capacity and Ca2+- triggered mitochondrial swelling of isolated mitochondria of SH-SY5Y cells step-by-step.

A Technique to Generate an Adjuvant-Induced Arthritis Mouse Model

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2025

This video demonstrates a method to generate adjuvant-induced arthritis in a murine model. Complete Freund's adjuvant (CFA) is injected in the mouse ankle joint and periarticular areas. CFA activates the immune system, leading to neutrophil infiltration and exaggerated inflammation.

Murine Model of Epicutaneously-Induced Immunomodulation

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2025

The study demonstrates the role of the skin in modulating immune responses in mice through epicutaneous (EC) immunization. EC immunization with a protein antigen can suppress immune responses in contact hypersensitivity or reverse skin-induced suppression when combined with pathogen-associated molecular patterns. EC immunization shows promise as an effective, needle-free approach to immunotherapy.

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