JoVE Encyclopedie van Experimenten
Neurowetenschap
0 weergaven • 2:18 min. • June 17th, 2025
Positron emission tomography, or PET, can measure glucose metabolism, which reflects neuronal activity within the brain.
To begin, position the participant on the scanner bed with a pre-inserted cannula.
Connect and secure the infusion tubing to deliver the tracer solution at a controlled rate throughout the scan.
Conduct a localizer scan to confirm the accurate positioning and verify PET parameters.
Initiate the PET acquisition, then begin the infusion of the tracer, 18-fluorine fluorodeoxyglucose (FDG), a glucose analog labeled with radioactive fluorine.
Within an active neuron, FDG is metabolized to FDG-6-phosphate and accumulates inside.
The radioactive fluorine undergoes decay, emitting a positron that interacts with a nearby electron, producing photon pairs traveling in opposite directions.
The PET detector records these emitted photons during the scan and generates a high-resolution image showing tracer distribution within the brain.
Position the participant in the scanner and cover with a disposable blanket to maintain a comfortable body temperature. Flush the cannula to ensure it is patent with minimal resistance before connecting the infusion line. Tape the tubing to the partici
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