Succesvolle orthotope levertransplantatie bij muizen met behulp van microcomputertomografie-angiografie

3.7K weergaven

Geciteerd door 2

09:23 min

22 september 2023

10.3791/65537-v

22 september 2023

3.7K weergaven

Qiang Zeng¹ , Doug A. Gouchoe²^,³ , Mahboubeh Nabavinia⁴ , Yong Gyu Lee² , Xi Wang² , Terri A. Shaffer⁵ , Mitchel R. Stacy⁴^,⁵^,⁶ , Blake R. Peterson⁷^,⁸ , Bryan A. Whitson²^,⁹ , Christopher Breuer¹^,⁴ , Sylvester M. Black¹^,¹⁰

¹Department of Surgery, Nationwide Children’s Hospital, ²COPPER Laboratory, The Ohio State University, ³88th Surgical Operation Operations Squadron, WPAFB, ⁴Center for Regenerative Medicine, The Research Institute at Nationwide Children’s Hospital, ⁵Division of Vascular Diseases and Surgery, The Ohio State University College of Medicine, ⁶Interdisciplinary Biophysics Graduate Program, The Ohio State University, ⁷Division of Medicinal Chemistry and Pharmacognosy, The Ohio State University College of Pharmacy, ⁸The Ohio State University Comprehensive Cancer Center, ⁹Division of Cardiac Surgery, Department of Surgery, The Ohio State Wexner Medical Center, ¹⁰Division of Transplantation, Department of Surgery, The Ohio State Wexner Medical Center

In dit protocol bespreken we de implementatie van een model van succesvolle orthotope levertransplantatie (OLT) bij muizen. Daarnaast worden ook adjuvantia besproken om de doorgankelijkheid van het transplantaat verder te analyseren na succesvolle OLT in een muis, met name met behulp van microcomputertomografie (microCT)-scans.